ArticleFrontiers in endocrinology2026
G-protein coupled estrogen receptor 1
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: In 2021, WHO classification of brain tumors adopted an integrated approach, combining histopathological features with key molecular alterations, notably redefining astrocytoma and glioblastoma entities. Among gliomas, glioblastoma has the worst prognosis, with a median patient survival rate of no more than 15 months. To date, no treatment is effective and there is no targeted therapy available. Recent research underscores the influence of sex and sex hormones in gliomagenesis, development and response to treatment. Indeed, glioblastoma exhibit sex-based disparities in adults, with a higher incidence of these tumors and shorter survival in males compared to females. Sex differences tend to narrow in older populations, suggesting that beside genetic sex or acquired gender-biased specificities, sex hormones play a significant role in this difference. Among the key hormone receptors potentially involved, we focused on GPER, the membrane g-coupled estrogen receptor. Methods: Expression, methylation and clinical data from TCGA-LGG and TCGA-GBM datasets were reclassified according to WHO 2021. Results: A high expression of Conclusion: The present findings identify a potential mechanism of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.