ArticleFrontiers in neuroscience2026
Non-motor correlates of anxiety in
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Anxiety is a prevalent early non-motor symptom of Parkinson's disease (PD), but its clinical correlates remain poorly defined in Methods: Anxiety was assessed with the Hamilton Anxiety Rating Scale; multivariate logistic regression and prespecified stratified analyses by age, sex, disease duration, Hoehn-Yahr stage and motor severity were performed. Results: Clinically significant anxiety was detected in 44.0% of PD patients versus 8.1% of controls ( Conclusion: These findings indicate that non-motor abnormalities, rather than motor impairment, are associated with anxiety in early PD after adjustment for demographic and motor covariates. The distinct correlative patterns across subgroups provide preliminary clinical clues for the heterogeneous neurodegenerative processes underlying PD-related anxiety, and support routine screening of depressive, sleep and olfactory symptoms to facilitate anxiety risk stratification at initial diagnosis.
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