Evidence map›Paper›PMID 42856736›Full record

ArticleExploration (Beijing, China)2026

Endogenous Trigeminal Neurons Induce Schwann Differentiation of Donor Stem Cells in Dental Pulp Regeneration via Reciprocal Extracellular Vesicles Interplay.

Wanmin Zhao, Wenzhe Wang, Jia Guo, Jiani Liu, Wei Wang, Dihao Tao, Jiayi Dong, Zhonghan Li, Shiyu Liu, Songtao Shi and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Exploration (Beijing, China), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wanmin Zhao *State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi International Joint Research Center For Oral Diseases Center For Tissue Engineering School of Stomatology The Fourth Military Medical University Xi'an China.
Wenzhe Wang *State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi International Joint Research Center For Oral Diseases Center For Tissue Engineering School of Stomatology The Fourth Military Medical University Xi'an China.
Jia Guo *State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi International Joint Research Center For Oral Diseases Center For Tissue Engineering School of Stomatology The Fourth Military Medical University Xi'an China.
Jiani Liu *State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi International Joint Research Center For Oral Diseases Center For Tissue Engineering School of Stomatology The Fourth Military Medical University Xi'an China.
Wei WangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi Key Laboratory of Stomatology Department of Endodontics School of Stomatology The Fourth Military Medical University Xi'an China.
Dihao TaoState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi International Joint Research Center For Oral Diseases Center For Tissue Engineering School of Stomatology The Fourth Military Medical University Xi'an China.
Jiayi DongState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi International Joint Research Center For Oral Diseases Center For Tissue Engineering School of Stomatology The Fourth Military Medical University Xi'an China.
Zhonghan LiCenter of Growth Metabolism and Aging Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education College of Life Sciences Sichuan University Chengdu China.
Shiyu LiuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi International Joint Research Center For Oral Diseases Center For Tissue Engineering School of Stomatology The Fourth Military Medical University Xi'an China.
Songtao ShiSouth China Center of Craniofacial Stem Cell Research Guanghua School of Stomatology Sun Yat-sen University Guangzhou China.
Tao ChenDepartment of Anatomy and K.K. Leung Brain Research Centre The Fourth Military Medical University Xi'an China.
Yan JinState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi International Joint Research Center For Oral Diseases Center For Tissue Engineering School of Stomatology The Fourth Military Medical University Xi'an China.
Bei LiState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi International Joint Research Center For Oral Diseases Center For Tissue Engineering School of Stomatology The Fourth Military Medical University Xi'an China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The potential of stem cells transplantation to restore organ function in recipients is hindered by the poor integration of donor cells into host tissues. Here, we successfully regenerated tooth pulp in the root canal of minipigs by transplanting human deciduous tooth stem cells (SHED). The implanted SHED differentiated into several functional cells, particularly Schwann cells (SCs), which attracted and enwrapped regrown host axons in regenerated pulp. The reciprocal extracellular vesicles (EVs) communication between SHED and the host trigeminal ganglion (TG) regulated the regeneration of dental nerves. EVs derived from SHED (SHED-EVs) facilitated axonal growth, while those released by TG neurons (TGN) induced the differentiation of SHED into SCs. TGN that engulfed SHED-EVs secreted endogenous EVs (ST-EVs) and migrated to the regenerated pulp tissue. ST-EVs from TGN are enriched with TUFM (Tu translation elongation factor, mitochondrial), which, in turn promotes Schwann cell differentiation (SC differentiation) of SHED. This study highlights the importance of cellular signal exchange during the integration of donor cells and host tissues for organ regeneration.

Indexed as

extracellular vesiclesmitochondriaschwann cellstissue regenerationtrigeminal ganglion

Identifiers

PMID42856736
PMCPMC13650028

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.