Evidence map›Paper›PMID 42856730›Full record

ArticleFrontiers in microbiology2026

DUF4004 protein BacR (YhbD) of

Kristin Velten, Patrik Brück, Shahla Alipour, Doreen Meier, Georg K A Hochberg, Paul Klemm, Marcus Lechner, Anke Becker, Peter L Graumann

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In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kristin VeltenSYNMIKRO, Center for Synthetic Microbiology, Philipps-University Marburg, Marburg, Germany.
Patrik BrückSYNMIKRO, Center for Synthetic Microbiology, Philipps-University Marburg, Marburg, Germany.
Shahla AlipourSYNMIKRO, Center for Synthetic Microbiology, Philipps-University Marburg, Marburg, Germany.
Doreen MeierSYNMIKRO, Center for Synthetic Microbiology, Philipps-University Marburg, Marburg, Germany.
Georg K A HochbergDepartment of Biology, Philipps-University Marburg, Marburg, Germany.
Paul KlemmSYNMIKRO, Center for Synthetic Microbiology, Philipps-University Marburg, Marburg, Germany.
Marcus LechnerSYNMIKRO, Center for Synthetic Microbiology, Philipps-University Marburg, Marburg, Germany.
Anke BeckerSYNMIKRO, Center for Synthetic Microbiology, Philipps-University Marburg, Marburg, Germany.
Peter L GraumannSYNMIKRO, Center for Synthetic Microbiology, Philipps-University Marburg, Marburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: DUF4004-containing proteins are found in a variety of bacteria. The only characterized member was shown to act as transcriptional repressor of genes involved in metabolism in Results: We propose to name the protein as "BacR" for bactofilin regulator. The putative transcription factor binds to DNA Discussion: Depletion of BacE and BacF leads to a loss of membrane localization of BacR and induces nucleoid association. These findings suggest that bactofilins can recruit BacR to the membrane. Treatment of cells with vancomycin also leads to a switch in BacR localization to the nucleoids, indicating that it may be involved in the response to cell wall stress. Our data suggest that BacR acts as a regulator of bactofilins, and fine-tunes bactofilin expression involving a switch-like mechanism with BacE and BacF.

Indexed as

Bacillus subtilisbactofilinscell wall stressDUF4004subcellular relocalizationtranscriptional regulation

Identifiers

PMID42856730
PMCPMC13649987

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.