Evidence map›Paper›PMID 42856715›Full record

ArticleResearch square2026

SQOR regulates H

Andras K Ponti, Taylor Gatesman, Sarah Hatem, Jordyn Smith, Ishana Senthil, Arjun Akula, Lilly Stanley, Matthew Godwin, Kewal Asosingh, Isaac Ampong and 7 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Andras K PontiDepartment of Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland, OH, USA.
Taylor GatesmanDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.
Sarah HatemDepartment of Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland, OH, USA.
Jordyn SmithDepartment of Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland, OH, USA.
Ishana SenthilDepartment of Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland, OH, USA.
Arjun AkulaDepartment of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA.
Lilly StanleyDepartment of Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland, OH, USA.
Matthew GodwinDepartment of Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland, OH, USA.
Kewal AsosinghDepartment of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Isaac AmpongShared Laboratory Resource, Cleveland Clinic Research, Cleveland, OH, USA.
Belinda WillardShared Laboratory Resource, Cleveland Clinic Research, Cleveland, OH, USA.ORCID 0000-0001-6884-6369
Naseer SangwanDepartment of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Andrew DhawanDepartment of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA.ORCID 0000-0002-5027-1277
Daniel J SilverDepartment of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA.ORCID 0000-0002-7085-2626
Sameer AgnihotriDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-6584-3795
Justin D LathiaDepartment of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA.ORCID 0000-0003-3168-7290
Christopher HineDepartment of Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland, OH, USA.ORCID 0000-0003-1926-7939

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) adapts to metabolic stress through mitochondrial pathways that are not fully defined. Here, we show sulfide quinone oxidoreductase (SQOR) is upregulated in human GBM and functions as a mitochondrial checkpoint linking hydrogen sulfide (H

Indexed as

Cancer metabolismCGLCSECTHCystathionine gamma lyaseGBMGlioblastomaH2SHydrogen sulfideKrebs CycleLipid dropletsLipid metabolismMitochondriaSQORSQRSQRDLSulfide oxidationSulfide quinone oxidoreductaseTCA cycleTranssulfuration

Identifiers

PMID42856715
PMCPMC13648848

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.