Evidence map›Paper›PMID 42856709›Full record

ArticleResearch square2026

Genomic Connectivity and Adaptive Gene Flow of

Fekadu Gemechu, Kelly L Bennett, Araya Eukubay, Sisay Dugassa, Anastasia Hernandez-Koutoucheva, Luna Kamau, Tadesse Kebede Zeleke, Alistair Miles, Deriba Abera, Chris S Clarkson and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fekadu GemechuAklilu Lemma Institute of Health Research, Center for Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.
Kelly L BennettLiverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.
Araya EukubayEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Sisay DugassaAklilu Lemma Institute of Health Research, Center for Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.
Anastasia Hernandez-KoutouchevaLiverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.
Luna KamauCentre for Biotechnology Research and Development, Kenya Medical Research Institute, Kenya.
Tadesse Kebede ZelekeDepartment of Microbiology, Immunology, and Parasitology, College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.
Alistair MilesEllison Institute of Technology, Littlemore, Oxford, OX4 4GE, UK.
Deriba AberaAklilu Lemma Institute of Health Research, Center for Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.
Chris S ClarksonLiverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.
Lemu GolassaAklilu Lemma Institute of Health Research, Center for Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.

Funding

Genome-based diagnostics for monitoring and evaluation of insecticide resistance in Anopheles gambiaeR01AI116811 · NIAID · TMLIVERPOOL SCHOOL OF TROPICAL MEDICINE · PI Martin James Donnelly · 2016 to 2026
$4.6M
Bill & Melinda Gates Foundation INV-001927NIAID NIH HHS R01 AI116811Wellcome Trust
6 · The paper itself

Abstract

Population connectivity influences the adaptive capacity of disease vectors by mediating the spread of insecticide resistance alleles. High gene flow poses challenges for tailored intervention strategies targeting localised populations, but connectivity is often poorly characterised for particular geographical regions. This study uses whole-genome data to investigate the population connectivity of the

Indexed as

Adaptive gene flowAnopheles gambiae s.s.East-Central AfricaEthiopiagenomic insecticide resistancegeographical population connectivitymalariawhole-genome sequencing

Identifiers

PMID42856709
PMCPMC13648852

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.