ArticleFrontiers in medicine2026
Effects of topical
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by immune dysregulation and impaired epidermal barrier function. Interleukin-22 (IL-22) contributes to epidermal inflammation and disrupts keratinocyte differentiation, whereas filaggrin is essential for maintaining epidermal barrier integrity. Objective: To evaluate the effects of topical Methods: This randomized posttest-only controlled animal study included 30 male BALB/c mice allocated to six groups ( Results: Cutaneous IL-22 concentrations differed significantly among groups (Kruskal-Wallis = 12.927, Conclusion: ABLEC at 0.02% and 0.04% were associated with lower cutaneous IL-22 concentrations than the untreated AD control, but similar reductions in the vehicle control precluded demonstration of an extract-specific effect. Furthermore, no statistically detectable difference in filaggrin expression or dose-response relationship was observed.
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Registered trials
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