Evidence map›Paper›PMID 42856668›Full record

SynthesisFrontiers in pharmacology2026

Natural product-derived interventions for reversing multidrug resistance in resistant K562 leukemia cells: a systematic review and meta-analysis.

Jingyi Sun, Changning Song, Yining Hua, Jiayin Pang, Shuaiting Sun

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jingyi SunSchool of Biomedical and Chemical Engineering, Liaoning Institute of Science and Technology, Benxi, China.
Changning SongSchool of Biomedical and Chemical Engineering, Liaoning Institute of Science and Technology, Benxi, China.
Yining HuaSchool of Biomedical and Chemical Engineering, Liaoning Institute of Science and Technology, Benxi, China.
Jiayin PangSchool of Biomedical and Chemical Engineering, Liaoning Institute of Science and Technology, Benxi, China.
Shuaiting SunSchool of Biomedical and Chemical Engineering, Liaoning Institute of Science and Technology, Benxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Multidrug resistance remains a major barrier to effective chemotherapy for leukemia. Natural product-derived interventions have been widely investigated as modulators of drug resistance in adriamycin- or doxorubicin-resistant K562 cell models, but their quantitative reversal effects remain heterogeneous. Methods: Results: Twenty-eight Conclusion: Across the heterogeneous studies, the common IC50-based endpoint showed an overall chemosensitization signal; however, this pooled summary does not imply a shared pharmacological action or potency across chemically distinct metabolites. Effect magnitude and mechanisms remained specific to individual metabolites, resistant-cell sublines, substrate drugs, doses, and molecular targets.

Indexed as

K562 leukemiameta-analysismultidrug resistancenatural productsreversal fold

Identifiers

PMID42856668
PMCPMC13649677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.