Evidence map›Paper›PMID 42856561›Full record

ArticlebioRxiv : the preprint server for biology2026

Autophagy dependent HIF1α proteostasis is compromised in models of PEX1 deficiencies.

Soham P Chowdhury, Sambhav Jain, Milagros Esmerode, Henry Dong, Jonathan T Vu, Connor J Sheedy, Chris D Richardson, Brooke M Gardner

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Soham P ChowdhuryDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA.ORCID 0009-0008-8321-8406
Sambhav JainDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA.ORCID 0009-0002-2312-456X
Milagros EsmerodeDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA.ORCID 0009-0008-5740-3501
Henry DongDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA.ORCID 0009-0007-6924-8900
Jonathan T VuInterdisciplinary Quantitative Biosciences Program, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA.ORCID 0000-0002-4950-7967
Connor J SheedyInterdisciplinary Quantitative Biosciences Program, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA.ORCID 0000-0002-9161-7182
Chris D RichardsonDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA.ORCID 0000-0003-3122-4851
Brooke M GardnerDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA.ORCID 0000-0001-7999-8827

Funding

MARC at the University of California Santa BarbaraT34GM136466 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Arica Ayalah Lubin, Joel H. Rothman · 2020 to 2026
$2.7M
Investigating the mechanisms of peroxisome homeostasisR35GM146784 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Brooke Meghan Gardner · 2022 to 2026
$2.1M
Defining DNA resection and protein localization changes that occur during DSB repairR35GM142975 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI RICHARDSON, CHRIS · 2021 to 2025
$1.9M
Investigating the role of AAA+-ATPases in peroxisome biologyR00GM121880 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI GARDNER, BROOKE MEGHAN · 2019 to 2021
$747k
NIGMS NIH HHS R00 GM121880NIGMS NIH HHS R35 GM142975NIGMS NIH HHS R35 GM146784NIGMS NIH HHS T34 GM136466
6 · The paper itself

Abstract

Peroxisomes, along with mitochondria, coordinate and compartmentalize oxidative metabolism in eukaryotic cells. Rare genetic disorders caused by mutations in PEX genes impair peroxisome function and cause Peroxisome Biogenesis Disorders, which are characterized by liver and neurological dysfunction, hearing and vision loss, and metabolic abnormalities. The majority of Peroxisome Biogenesis Disorders (PBDs) are caused by mutations in the gene encoding PEX1, which together with PEX6 forms a hetero-hexameric AAA-ATPase complex that drives the import of enzymes into the peroxisome lumen. One particular destabilizing mutation - PEX1

Indexed as

autophagycell signalinghypoxiahypoxia-inducible factor (HIF)Peroxisomeproteostasis

Identifiers

PMID42856561
PMCPMC13648651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.