ArticlebioRxiv : the preprint server for biology2026
Novel Co-expression of Group I Metabotropic Glutamate Receptor During Mouse Cochlear Nucleus Development.
Hitomi Sakano, Jason Wheeler, Justine Lam, Erik Vo, Robin Gibson, Jake Langevin, Xiaoyan Yu, Edwin W Rubel, Yuan Wang
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Hitomi SakanoDepartment of Otolaryngology, University of Rochester Medical Center, Rochester, NY, United States.ORCID 0000-0002-7471-8352 Jason WheelerDepartment of Otolaryngology, University of Rochester Medical Center, Rochester, NY, United States.
Justine LamDepartment of Otolaryngology, University of Rochester Medical Center, Rochester, NY, United States.
Erik VoDepartment of Otolaryngology-Head & Neck Surgery, Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Robin GibsonVirginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, WA, United States.
Jake LangevinDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, United States.
Xiaoyan YuDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, United States.ORCID 0000-0002-4877-0114 Edwin W RubelVirginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, WA, United States.
Yuan WangDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, United States.ORCID 0000-0003-4347-7063 Funding
Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)P30AR069655 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2016 to 2026
$7.8MAxonal FMRP in Synaptic DevelopmentR01MH126176 · NIMH · FLORIDA STATE UNIVERSITY · PI WANG, YUAN · 2021 to 2025
$2.0MRole of Fragile X Mental Retardation Protein on Gene Expression in Auditory Brainstem DevelopmentK08DC019416 · NIDCD · UT SOUTHWESTERN MEDICAL CENTER · PI SAKANO, HITOMI · 2021 to 2025
$915kMetabotropic Glutamate Receptor-Mediated Neuromodulation in Sound Localization CircuitsR56DC016054 · NIDCD · NORTHEAST OHIO MEDICAL UNIVERSITY · PI LU, YONG · 2023 to 2023
$629kNIAMS NIH HHS P30 AR069655NIDCD NIH HHS K08 DC019416NIDCD NIH HHS R56 DC016054NIMH NIH HHS R01 MH126176
6 · The paper itselfAbstract
Metabotropic glutamate receptors (mGluR) are G-protein coupled receptors that regulate neuroplasticity and have been shown to play a role in auditory processing. However, not much is known about the expression of mGluRs during cochlear nucleus development in the context of Fragile X syndrome (FXS). FXS is the most common heritable form of intellectual disability and autism and is associated with auditory processing deficits including hypersensitivity. Audiogenic seizure is a notable feature of the
Indexed as
auditory critical periodcochlear nucleusFmr1FMRPFragile XmGluR1mGluR5
Identifiers
PMID42856495
PMCPMC13648617
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