Evidence map›Paper›PMID 42856493›Full record

ArticlebioRxiv : the preprint server for biology2026

A Novel Biofilm Amyloid Ligand for Caspase-11 Drives Hyperactivation in Dendritic Cells.

Shrutika Mintri, Guangnan Hu, Anukriti Mathur, Leah M Whiteman, Alexandre Dinis, Brian Le, Kaitlyn Grando, Patience Shumba, Vijay A Rathinam, Egil Lien and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shrutika MintriLaboratory of Dendritic Cell Biology, Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01545, USA.ORCID 0009-0006-5007-7702
Guangnan HuLaboratory of Dendritic Cell Biology, Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01545, USA.ORCID 0000-0003-1570-6770
Anukriti MathurDivision of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01545, USA.ORCID 0000-0002-7004-301X
Leah M WhitemanLaboratory of Dendritic Cell Biology, Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01545, USA.ORCID 0009-0001-2297-5998
Alexandre DinisDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01545, USA.ORCID 0000-0002-6813-6380
Brian LeLaboratory of Dendritic Cell Biology, Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01545, USA.ORCID 0009-0008-0913-460X
Kaitlyn GrandoCenter for Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.ORCID 0009-0000-4328-8639
Patience ShumbaDepartment of Immunology, University of Connecticut Health School of Medicine, Farmington, CT, 06030, USA.ORCID 0000-0002-1105-0308
Vijay A RathinamDepartment of Immunology, University of Connecticut Health School of Medicine, Farmington, CT, 06030, USA.ORCID 0000-0002-8009-3977
Egil LienDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01545, USA.ORCID 0000-0002-8536-2419
Çağla TükelCenter for Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.ORCID 0000-0001-7073-0226
Katherine A FitzgeraldDivision of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01545, USA.ORCID 0000-0003-3175-609X
Stefania GallucciLaboratory of Dendritic Cell Biology, Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01545, USA.ORCID 0000-0003-4737-8003

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial biofilms drive persistent infection and chronic inflammation, yet host sensing of biofilm-derived ligands remains poorly understood. Here we identify curli amyloid, an integral component of

Identifiers

PMID42856493
PMCPMC13648619

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.