ArticleFrontiers in medicine2026
Regression of severe sclerotic chronic graft-versus-host disease after a second haploidentical hematopoietic stem cell transplantation: a case report.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Sclerotic chronic graft-versus-host disease (Scl-cGVHD) is a disabling fibrotic manifestation of cGVHD and frequently exhibits poor responsiveness to conventional immunosuppressive therapy. Therapeutic options remained limited, particularly in pediatric patients. An 8-year-old boy with relapsed acute myeloid leukemia underwent matched sibling donor allogeneic hematopoietic stem cell transplantation (allo-HSCT) in January 2021. Four months later, he developed progressive cutaneous cGVHD that evolved into severe Scl-cGVHD, with diffuse skin thickening, painful fissures, ulceration, and multiple joint contractures, loss of independent ambulation, and complete dependence in activities of daily living. Skin biopsy demonstrated extensive dermal fibrosis, collagen deposition, and increased
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