Evidence map›Paper›PMID 42856468›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Methylation-associated Gene Expression (MaGE): a non-invasive, in vivo measure of cellular senescence.

Daniel J Simpson, Samuel J Crofts, Christos Mavrommatis, Thomas A White, Yossawat Suwanlikit, Kirstyn Loyva, Walter A Rocca, Kejal Kantarci, Michelle M Mielke, Anne Richmond and 4 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Daniel J SimpsonRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester MN, USA.ORCID 0000-0002-8431-7384
Samuel J CroftsRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester MN, USA.ORCID 0000-0001-7496-082X
Christos MavrommatisRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester MN, USA.
Thomas A WhiteRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester MN, USA.
Yossawat SuwanlikitRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester MN, USA.ORCID 0000-0002-5795-7888
Kirstyn LoyvaRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester MN, USA.
Walter A RoccaDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester MN, USA.
Kejal KantarciDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Michelle M MielkeDepartment of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0001-7177-1185
Anne RichmondInstitute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Riccardo E MarioniInstitute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-4430-4260
Kristina KirschnerRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester MN, USA.ORCID 0000-0001-7607-8670
Nathan K LebrasseurRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester MN, USA.ORCID 0000-0002-2002-0418
Tamir ChandraRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester MN, USA.ORCID 0000-0002-7935-317X

Funding

Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's DiseaseU54AG044170 · NIA · MAYO CLINIC ROCHESTER · PI KAPOOR, EKTA · 2018 to 2022
$7.7M
NIA NIH HHS U54 AG044170Wellcome Trust
6 · The paper itself

Abstract

Cellular senescence is a central hallmark of aging, yet its measurement in humans remains invasive, low-throughput and tissue-specific, precluding population-scale study. We developed Methylation-associated Gene Expression (MaGE) predictors: whole-blood DNA methylation proxies of p14

Identifiers

PMID42856468
PMCPMC13648841

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.