Evidence map›Paper›PMID 42856463›Full record

ArticlebioRxiv : the preprint server for biology2026

Tumor suppressor-like mutations mark a dosage-constrained dependency in leukemia.

Jonathan D Lee, Madison M Uyemura, Francisca Lamini, Ryan R Posey, Ellie H Shin, Amyah C Harris, Tiziana Ottone, Giulia Cheloni, David B Chou, Bon Q Trinh and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jonathan D LeeDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Madison M UyemuraDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Francisca LaminiDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Ryan R PoseyWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Ellie H ShinDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Amyah C HarrisDepartment of Hematology/Oncology, Massachusetts General Brigham Cancer Institute and Harvard Medical School, Boston, MA, USA.
Tiziana OttoneTor Vergata University, Department of Biomedicine and Prevention, Rome, Italy.
Giulia CheloniDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
David B ChouWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Bon Q TrinhDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Joao A PauloDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.
Daniel G TenenHarvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.
John G ClohessyDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Maria Teresa VosoTor Vergata University, Department of Biomedicine and Prevention, Rome, Italy.
Timothy A GraubertDepartment of Hematology/Oncology, Massachusetts General Brigham Cancer Institute and Harvard Medical School, Boston, MA, USA.
Frank J SlackDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Funding

Transcriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Jason Daniel Buenrostro · 2017 to 2026
$24.6M
Precision microRNA medicine in cancerR35CA232105 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SLACK, FRANK J. · 2019 to 2025
$7.2M
Advancing Multiplexed Isobaric Tag-based Strategies for Proteome ProfilingR01GM132129 · NIGMS · HARVARD MEDICAL SCHOOL · PI PAULO, JOAO A · 2019 to 2023
$1.7M
Deciphering the Transcriptomic Basis of Chemo FogK99CA293268 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Jonathan D Lee · 2025 to 2026
$271k
NCI NIH HHS K99 CA293268NCI NIH HHS R35 CA232105NHLBI NIH HHS P01 HL131477NIGMS NIH HHS R01 GM132129
6 · The paper itself

Abstract

Cancer genes are classically categorized as oncogenes or tumor suppressors based on whether gain or loss of function promotes malignancy. Here we show that oncogene-imposed dosage constraints can produce mutations that mimic tumor suppressor loss yet mark essential genes. In acute promyelocytic leukemia (APL), the transcription factor

Identifiers

PMID42856463
PMCPMC13648656

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.