Evidence map›Paper›PMID 42856459›Full record

ArticlebioRxiv : the preprint server for biology2026

Functional Divergence in Gut Clostridia from Hadza Hunter-Gatherers Reveals Diet-Adapted Metabolic Machinery That Shapes Gut Ecology.

Tadashi Takeuchi, Anita Reddy, Elektra K Robinson, Kent Masakazu Kotaka, Steven K Higginbottom, Erica D Sonnenburg, Justin L Sonnenburg

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tadashi TakeuchiDepartment of Microbiology and Immunology, Stanford University, Stanford, CA, 94305, USA.ORCID 0000-0003-1693-7490
Anita ReddyDepartment of Microbiology and Immunology, Stanford University, Stanford, CA, 94305, USA.
Elektra K RobinsonDepartment of Microbiology and Immunology, Stanford University, Stanford, CA, 94305, USA.
Kent Masakazu KotakaBiophysics Program, Stanford University, Stanford, CA 94305, USA.
Steven K HigginbottomDepartment of Microbiology and Immunology, Stanford University, Stanford, CA, 94305, USA.
Erica D SonnenburgDepartment of Microbiology and Immunology, Stanford University, Stanford, CA, 94305, USA.
Justin L SonnenburgDepartment of Microbiology and Immunology, Stanford University, Stanford, CA, 94305, USA.

Funding

Impact of Diet on Intestinal Microbiota-Host DynamicsR01DK085025 · NIDDK · STANFORD UNIVERSITY · PI JUSTIN L SONNENBURG · 2010 to 2026
$6.4M
Restoring Key Functions to the Industrialized Gut MicrobiomeR01AT013330 · NCCIH · STANFORD UNIVERSITY · PI Eric C Martens, JUSTIN L SONNENBURG · 2026 to 2026
$787k
Harnessing Metabolic Machinery of Gut Bacteria for Metabolic Dysfunction-Associated SteatohepatitisK99DK146142 · NIDDK · STANFORD UNIVERSITY · PI Tadashi Takeuchi · 2026 to 2026
$92k
NCCIH NIH HHS R01 AT013330NIDDK NIH HHS K99 DK146142NIDDK NIH HHS R01 DK085025
6 · The paper itself

Abstract

Lifestyle changes associated with industrialization, including shifts in diet, are linked to extensive remodeling of the human gut microbiome. Investigating the gut microbiomes of traditional populations living non-industrialized lifestyles, such as the Hadza hunter-gatherers of Tanzania, therefore offers insight into bacterial taxa and functions depleted in industrialized microbiomes. Despite pronounced compositional differences that correspond to lifestyle, many commensal gut species are shared between industrialized and non-industrialized populations, raising a fundamental question of whether and how their functional repertoires diverge across contrasting gut environments. Here, by integrating strain-resolved metagenomics with culturomics and

Identifiers

PMID42856459
PMCPMC13648662

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.