Evidence map›Paper›PMID 42856454›Full record

ArticleResearch square2026

Language of Hope in Conversations between Pediatric Oncologists, Children with Advanced Cancer, and their Families.

Nidhi Vij Mali, Carolyn Humphrey, Amy Porter, Erica Carmen Kaye, Alexandra Kathleen Superdock

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nidhi Vij MaliSt. Jude Children's Research Hospital.
Carolyn HumphreyUniversity of Mississippi.
Amy PorterMassachusetts General Hospital.
Erica Carmen KayeSt. Jude Children's Research Hospital.
Alexandra Kathleen SuperdockSt. Jude Children's Research Hospital.

Funding

IMPROVING PROGNOSTIC COMMUNICATION IN PEDIATRIC CANCERK08CA266935 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Erica Carmen Kaye · 2022 to 2026
$1.0M
Pediatric Oncology Career Development Program at St. JudeK12CA270369 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Elizabeth Fox, CHARLES ROBERTS · 2024 to 2026
$793k
NCI NIH HHS K08 CA266935NCI NIH HHS K12 CA270369
6 · The paper itself

Abstract

Purpose: Hope is a key driver of coping and decision-making for children with cancer and their families. Prior studies have shown that hope is bolstered, not fractured, by high-quality prognostic communication. However, clinicians describe a tension between conveying hope and honestly discussing poor prognosis. This prospective longitudinal observational study aimed to identify and characterize communication approaches used by oncologists and parents to navigate hope in the context of poor prognosis. Methods: Serial conversations between pediatric patients with poor-prognosis brain tumors, their families, and their medical teams were audio-recorded at disease reevaluation timepoints for up to 24 months or until death. Rapid qualitative analysis was used to characterize the frequency and content of hope-related dialogue. Results: 132 conversations were recorded for 30 brain tumor patient-parent-oncologist triads.Hope-related dialogue was identified in 73 (55%) of encounters. Oncologists introduced hope language in about two-thirds of these conversations. Hope dialogue could be described along two dimensions: temporal orientation and desired outcomes. Temporally, hope appeared in conversations as prospective, retrospective, or negated. Desired outcomes included hope for cure, hope for remission, hope for life prolongation and meaningful experiences, and hope for symptom management and comfort at the end of life. Conclusion: Hope dialogue may be an entry point for aligning with families, exploring prognostic understanding, and opening the door to deeper conversations about reframing hopes and goals of care. Future work should explore development of strategies to elicit and respond to patient and family hopes across the cancer trajectory.

Indexed as

Breaking Bad NewsCommunicationGoals of CareHopeParentsPediatric Cancer

Identifiers

PMID42856454
PMCPMC13648844

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.