Evidence map›Paper›PMID 42856394›Full record

ArticlebioRxiv : the preprint server for biology2026

Core NHEJ Factors Maintain Synapsis Across Diverse DNA End Structures.

Brandon C Case, Isabel T Burger, Joseph J Loparo

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brandon C CaseDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, United States.ORCID 0000-0001-7259-0431
Isabel T BurgerDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, United States.ORCID 0000-0002-0133-8906
Joseph J LoparoDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, United States.ORCID 0000-0003-4941-4696

Funding

Mechanisms of Error-Prone DNA RepairR35GM158214 · NIGMS · HARVARD MEDICAL SCHOOL · PI Joseph J. Loparo · 2025 to 2026
$1.2M
Investigating DNA end-processing during non-homologous end joiningF32GM143844 · NIGMS · HARVARD MEDICAL SCHOOL · PI CASE, BRANDON C · 2022 to 2022
$68k
NIGMS NIH HHS F32 GM143844NIGMS NIH HHS R35 GM158214
6 · The paper itself

Abstract

DNA double strand breaks (DSBs) generated by genotoxic stress frequently contain chemically diverse termini that require end processing before ligation by non-homologous end joining (NHEJ). How end chemistry influences assembly and persistence of NHEJ synaptic complexes remains unclear. Using single-molecule imaging approaches in

Identifiers

PMID42856394
PMCPMC13648723

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.