Evidence map›Paper›PMID 42856324›Full record

ArticlebioRxiv : the preprint server for biology2026

Developmental Convergence Across Diverse Genetic Architectures in Childhood Apraxia of Speech.

Tiffanie White, Marjan Chapi, Caitlin Raaz, Laurel Bruce, Akshit Modi, Valentin Dinu, Li Liu, Judith Klein-Seetharaman, Beate Peter

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tiffanie WhiteKrieger School of Arts and Sciences, The Johns Hopkins University, Baltimore, MD, USA.ORCID 0009-0009-3816-8523
Marjan ChapiCollege of Health Solutions, Arizona State University, Phoenix, AZ, USA.ORCID 0009-0009-8938-2773
Caitlin RaazDepartment of Communication Sciences and Disorders, University of Northern Colorado, Greeley, CO, USA.ORCID 0000-0003-2172-3630
Laurel BruceCollege of Health Solutions, Arizona State University, Phoenix, AZ, USA.ORCID 0000-0002-9620-3157
Akshit ModiCollege of Health Solutions, Arizona State University, Phoenix, AZ, USA.ORCID 0009-0004-8405-5945
Valentin DinuCollege of Health Solutions, Arizona State University, Phoenix, AZ, USA.ORCID 0001-6192-7836
Li LiuCollege of Health Solutions, Arizona State University, Phoenix, AZ, USA.ORCID 0000-0003-4002-7497
Judith Klein-SeetharamanCollege of Health Solutions, Arizona State University, Phoenix, AZ, USA.ORCID 0000-0002-4892-6828
Beate PeterCollege of Health Solutions, Arizona State University, Phoenix, AZ, USA.ORCID 0000-0002-9083-8522

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Childhood apraxia of speech (CAS) is a neurodevelopmental disorder of speech-motor planning and programming, associated with literacy, academic, and psychosocial difficulties. We performed whole-exome sequencing in 11 families comprising 21 affected and 15 unaffected individuals with phenotyping spanning speech, language, cognition, literacy, and motor function. We identified 60 prioritized variant observations representing 22 unique variants across 20 genes with family-based segregation analysis assessed in informative relatives; 5 arose

Indexed as

Childhood Apraxia of SpeechCRISPR interference Perturb-seqEarly Developmental Brain TranscriptomicsNeurodevelopmentRare Genetic VariantsWhole-Exome Sequencing

Identifiers

PMID42856324
PMCPMC13648706

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.