Evidence map›Paper›PMID 42856300›Full record

ArticlebioRxiv : the preprint server for biology2026

Age-Dependent Effects of Macrophage Derived Cathelicidin Antimicrobial Peptide on Bone Fracture Repair.

Tuyet Nguyen, Yasuhito Yahara, Eijiro Shimada, Vijitha Puviindran, Puviindran Nadesan, Koji Ishikawa, Choiselle Marius, Benjamin Alman

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tuyet NguyenDepartment of Orthopaedics, Duke University, Durham, North Carolina, USA 27710.ORCID 0000-0002-8769-9955
Yasuhito YaharaDepartment of Orthopaedics, Duke University, Durham, North Carolina, USA 27710.
Eijiro ShimadaDepartment of Orthopaedics, Duke University, Durham, North Carolina, USA 27710.
Vijitha PuviindranDepartment of Orthopaedics, Duke University, Durham, North Carolina, USA 27710.
Puviindran NadesanDepartment of Orthopaedics, Duke University, Durham, North Carolina, USA 27710.
Koji IshikawaDepartment of Orthopaedics, Duke University, Durham, North Carolina, USA 27710.ORCID 0000-0003-3689-5662
Choiselle MariusDepartment of Orthopaedics, Duke University, Durham, North Carolina, USA 27710.
Benjamin AlmanDepartment of Orthopaedics, Duke University, Durham, North Carolina, USA 27710.ORCID 0000-0002-7302-122X

Funding

Training Program in Developmental & Stem Cell BiologyT32HD040372 · NICHD · DUKE UNIVERSITY · PI Terry H Lechler · 2001 to 2026
$8.9M
The role of macrophage subpopulations in the rejuvenation of fracture repairR01AG072058 · NIA · DUKE UNIVERSITY · PI ALMAN, BENJAMIN AARON · 2021 to 2025
$2.1M
NIA NIH HHS R01 AG072058NICHD NIH HHS T32 HD040372
6 · The paper itself

Abstract

The pace of fracture repair declines with age, increasing the risk of delayed union and nonunion. Delayed union and nonunion are associated with significant morbidity and even mortality with few effective non-surgical interventions. Here, we identify cathelicidin antimicrobial peptide (CAMP) as an age-dependent regulator of bone repair. Single-cell RNA sequencing and immunohistochemistry demonstrated higher CAMP expression during fracture healing in young compared with aged mice. Global or myeloid lineage-depletion of

Identifiers

PMID42856300
PMCPMC13648658

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.