Evidence map›Paper›PMID 42856215›Full record

ArticlebioRxiv : the preprint server for biology2026

Chronic semaglutide treatment attenuates cue-induced reinstatement of cocaine-seeking and cocaine-induced stereotypy in male and female rats.

Christopher A Turner, Natalia Morales Pagán, Daniela Pereira, Eileen Y Sun, Rachel E Himelhoch, Stephen E Chang, Shelly B Flagel

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christopher A TurnerMichigan Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA, 48109.ORCID 0009-0001-1724-5536
Natalia Morales PagánNeuroscience Graduate Program, University of Michigan, Ann Arbor, Michigan, USA, 48109.
Daniela PereiraNeuroscience Graduate Program, University of Michigan, Ann Arbor, Michigan, USA, 48109.
Eileen Y SunDepartment of Psychology, College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Rachel E HimelhochDepartment of Psychology, College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Stephen E ChangMichigan Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA, 48109.
Shelly B FlagelMichigan Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA, 48109.

Funding

University of Michigan Postbaccalaureate Research Education Program (UM PREP)R25GM086262 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALLEN, BENJAMIN · 2009 to 2024
$6.1M
NIDA Training Program in Neuroscience-Administrative SupplementT32DA007281 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Shelly Beth Flagel · 1995 to 2026
$5.7M
Postdoctoral Training in the Biology of Drug AbuseT32DA060142 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI John R. Traynor · 2024 to 2026
$1.5M
NIDA NIH HHS T32 DA007281NIDA NIH HHS T32 DA060142NIGMS NIH HHS R25 GM086262
6 · The paper itself

Abstract

Following cocaine self-administration, male and female rats received daily semaglutide during a 30-day abstinence period before cue- and cocaine-induced reinstatement tests. Semaglutide attenuated cue-induced reinstatement and cocaine-induced stereotypy, although operant responding was elevated following cocaine priming. These findings support further investigation of semaglutide as a treatment for cocaine use disorder.

Identifiers

PMID42856215
PMCPMC13648365

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.