Evidence map›Paper›PMID 42856144›Full record

ArticlebioRxiv : the preprint server for biology2026

TM6SF2 is a cholesterol-bound homomultimeric ER membrane protein that binds ApoB and is required for bulk lipidation of VLDL.

Sen Hong, Jin Wang, Matthew A Mitsche, Jonathan C Cohen, Xiaochun Li, Helen H Hobbs

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sen HongThe Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Jin WangThe Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Matthew A MitscheCenter for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Jonathan C CohenCenter for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Xiaochun LiDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Helen H HobbsThe Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

Funding

Tissue Culture & Antibody Production CoreP01HL160487 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Helen Haskell Hobbs · 2022 to 2026
$14.9M
Role of PNPLA3 in Fatty Liver DiseaseR01DK090066 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JONATHAN Charles COHEN, Helen Haskell Hobbs · 2011 to 2026
$7.8M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JOEL K. ELMQUIST · 2022 to 2026
$7.4M
Structural and Functional Investigations on Cholesterol Signaling and MetabolismR35GM149533 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Xiaochun Li · 2023 to 2026
$1.9M
NHLBI NIH HHS P01 HL160487NIDDK NIH HHS P30 DK127984NIDDK NIH HHS R01 DK090066NIGMS NIH HHS R35 GM149533
6 · The paper itself

Abstract

A missense variant in TM6SF2 (transmembrane 6 superfamily member 2, TM6SF2

Identifiers

PMID42856144
PMCPMC13648352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.