Evidence map›Paper›PMID 42855945›Full record

ArticleChemistry & biodiversity2026

Chemical Composition and Multi-Target Bioactivity of Salvia sclarea L. Essential Oil From the Algerian Edough Massif: Antimicrobial, Enzyme-Inhibitory, and Molecular Docking Studies.

Manel Lina Djendi, Chahrazed Benzaid, Ali Dekir, Houssem Chenna, Fouzia Trea, Sarah Rahal, Lina Raghad Klaiaia, Sağlam Kübra

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Manel Lina DjendiFaculty of Sciences, Department of Biochemistry, Laboratory of Microbiology and Molecular Biology (LMMB), Badji-Mokhtar-Annaba University, Annaba, Algeria.
Chahrazed BenzaidFaculty of Sciences, Department of Biochemistry, Laboratory of Microbiology and Molecular Biology (LMMB), Badji-Mokhtar-Annaba University, Annaba, Algeria.ORCID https://orcid.org/0000-0002-4881-4199
Ali DekirFaculty of Sciences, Department of Chemistry, Badji-Mokhtar-Annaba University, Annaba, Algeria.ORCID https://orcid.org/0009-0000-9604-4056
Houssem ChennaPharmaceutical Sciences Research Center (CRSP), Constantine, Algeria.ORCID https://orcid.org/0000-0003-0213-1517
Fouzia TreaFaculty of Sciences, Department of Biology, Laboratory of Environmental Biosurveillance (LBSE), Badji-Mokhtar-Annaba University, Annaba, Algeria.
Sarah RahalFaculty of Sciences, Department of Biochemistry, Laboratory of Microbiology and Molecular Biology (LMMB), Badji-Mokhtar-Annaba University, Annaba, Algeria.ORCID https://orcid.org/0000-0001-6830-0825
Lina Raghad KlaiaiaFaculty of Sciences, Department of Biochemistry, Laboratory of Microbiology and Molecular Biology (LMMB), Badji-Mokhtar-Annaba University, Annaba, Algeria.
Sağlam KübraDepartment of Food Processing, Food Technology Program, Istanbul Gelisim Vocational School, Istanbul Gelisim University, İstanbul, Türkiye.ORCID https://orcid.org/0000-0002-3564-7934

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Salvia sclarea L. (clary sage) is widely used in Algerian traditional medicine, yet its essential oil from the Edough Mountains (northeastern Algeria) remains poorly characterized. An ethnobotanical survey among 85 informants revealed high recognition (RFC = 0.918) and versatility (UV = 1.671), with predominant uses against digestive, nervous, and gynecological disorders (ICF up to 0.88). Hydrodistillation of the aerial parts yielded 1.90% (w/w) of a pale-yellow essential oil dominated by oxygenated monoterpenes (68.95%), mainly linalyl anthranilate (47.75%), and linalool (16.24%). The oil showed potent antimicrobial activity (MIC 15.32-1000 µg/mL), strong antibiofilm effects (up to 76.02% inhibition), remarkable antioxidant capacity (DPPH EC

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsCholinesterase InhibitorsMolecular Docking SimulationOils, VolatileSalviaAcetylcholinesteraseAlgeriaAntioxidantsCyclooxygenase 2HumansMicrobial Sensitivity TestsPlant Components, AerialStructure-Activity RelationshipAcetylcholinesteraseAnti-Bacterial AgentsAnti-Infective AgentsAntioxidantsCholinesterase InhibitorsCyclooxygenase 2Oils, Volatileacetylcholinesterase inhibitionAlgerian essential oilmolecular docking and dynamicsmulti‐target bioactivitySalvia sclarea

Identifiers

PMID42855945
PMCPMC13653116

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.