Evidence map›Paper›PMID 42855917›Full record

ArticleChemistry & biodiversity2026

Chlorothiophene-Substituted N-Phenylpyrazolines: Synthesis, Anticancer Evaluation, and Computational Insight into COX-2 Inhibition.

Nikma Farismatur Riza, Fia Fathiana Wulan, Tegar Asanda Ghifari, Endang Astuti, Tutik Dwi Wahyuningsih

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nikma Farismatur RizaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Fia Fathiana WulanDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Tegar Asanda GhifariDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Yogyakarta, Indonesia.ORCID https://orcid.org/0009-0000-3278-061X
Endang AstutiDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Tutik Dwi WahyuningsihDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Yogyakarta, Indonesia.ORCID https://orcid.org/0000-0001-5741-2848

Funding

Indonesian Ministry of Finance 0003002/IPA/M/2/lpdp2022Indonesian Ministry of Higher Education, Science, and Technology 2616/UN1/DITLIT/Dit-Lit/PT.01.03/2025
6 · The paper itself

Abstract

Cancer remains a leading cause of mortality worldwide, highlighting the need for novel anticancer agents. Pyrazoline derivatives have attracted considerable interest due to their structural flexibility, enabling modifications, including bioisosteric replacement, to enhance anticancer potential. In this study, eight N-phenylpyrazoline analogs bearing chlorothiophene moieties were synthesized via cyclocondensation of chalcone intermediates with phenylhydrazine, yielding 59%-94%. Structural characterization was confirmed using ATR-IR, GC-MS,

Indexed as

Antineoplastic AgentsCyclooxygenase 2Cyclooxygenase 2 InhibitorsPyrazolesThiophenesAnimalsCell Line, TumorCell ProliferationChlorocebus aethiopsDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipVero CellsAntineoplastic AgentsCyclooxygenase 2Cyclooxygenase 2 InhibitorsPyrazolesThiophenesanticancerbioisostericchlorothiopheneN‐phenylpyrazoline

Identifiers

PMID42855917
PMCPMC13653149

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.