ArticlePhysiological reports2026
Influence of exogenous glucagon-like peptide 2 on mechanisms of enteric neurotransmitter-mediated vasorelaxation in the isolated bovine mesenteric artery and vein.
Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Exogenous glucagon-like peptide 2 (GLP-2) administration increases small intestinal growth and mesenteric blood flow, although the vascular mechanisms involved remain unclear. The objective of this study was to characterize the effects of exogenous GLP-2 administration on glucagon-like peptide 2 (GLP-2)-, vasoactive intestinal peptide (VIP)-, serotonin (5-HT)-, and acetylcholine (ACh)-mediated vascular relaxation in isolated bovine mesenteric arteries (MA) and mesenteric veins (MV). Ten steers received repeated subcutaneous injections of bovine serum albumin or GLP-2 for 48 h before vessel collection. Vascular dimensions, vasoactive responses using myography, and mRNA expression of receptors associated with vasorelaxation were evaluated. Exogenous GLP-2 did not directly induce vasorelaxation in isolated MA or MV despite detectable GLP2R mRNA expression in both vessels, suggesting that GLP-2-mediated increases in mesenteric blood flow occur through indirect mechanisms. Vasoactive intestinal peptide induced dose-dependent vasorelaxation in both vessel types, and only VIPR2 mRNA was detected. Serotonin-mediated responses were not altered by exogenous GLP-2 treatment. In contrast, exogenous GLP-2 enhanced ACh-mediated vasorelaxation in the MA at greater agonist concentrations and increased NOS3 mRNA expression in the MV. These findings suggest that cholinergic signaling pathways may contribute to GLP-2-associated vasoregulation in the bovine MA.
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