ArticleNeurological research and practice2026
Deep brain stimulation for arm tremor: one-year blinded follow-up of a randomized trial.
Article in Neurological research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03156517 (Deep Brain Stimulation in Disabling Action Tremor), which is not on this map. Not yet cited in PubMed.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Deep Brain Stimulation in Disabling Action Tremor: A Randomized, Double-blind Study Comparing the Ventral Intermediate Nucleus (VIM) of the Thalamus and the Posterior Subthalamic Area (PSA) / Zona Incerta (The TREMORSTIM Study)
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Authors and funding
8 authors.
Funding
Abstract
objectiveTo present the secondary endpoints at one-year blinded follow-up from our randomized controlled study, that compared the efficacy of DBS in the ventral-intermediate thalamic nucleus (VIM) with the posterior subthalamic area (PSA) three months each in crossover design, and showed significantly greater reduction of the Sum dominant arm tremor score (Fahn-Tolosa-Marin) during the PSA-DBS period. The outcomes at one year are now reported to verify target choice and sustained benefit with clinically optimized free programming.
methodsForty-five patients with isolated or combined arm action tremor received four-level DBS leads to reach both VIM (upper two levels) and PSA (lower two), and were randomized post-operatively to VIM-DBS month 1-3 followed by PSA-DBS month 4-6, or vice versa. Thereafter electrode choice was free as judged by best clinical outcome. Predefined secondary endpoints were the tremor score improvements from preoperative to the one-year follow-up for dominant and non-dominant arm, other body regions, total score, two patient-rated measures and adverse events.
resultsAt the one-year follow-up, Sum dominant arm tremor scores had improved from median 24 at baseline to 4 (p<.001, n = 43), corresponding to median 79% improvement. All other secondary endpoints also improved significantly (p<.001). Median action tremor improvement was for Essential tremor(ET) 83%, for Parkinson´s disease(PD) and Dystonic tremor 100% and for Cerebellar tremor 55%. Over 90% of stimulated contacts were in PSA.
interpretationAt one year, good and sustained tremor suppression from PSA-DBS was confirmed in ET, PD and Dystonic tremor. Suppression of Cerebellar tremor was more variable.
trial registrationNCT03156517, May 29, 2017.
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Registered trials
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