Evidence map›Paper›PMID 42855730›Full record

ArticleBiomarker research2026

Pannexin 1 expression in circulating progenitor marker-positive cells is associated with senescence and cardiovascular risk.

Ting-Yi Tien, Chiung-Yin Chang, Yih-Jer Wu, Chao-Feng Lin, Yi-Nan Lee, Hsin-I Lee, Yen-Hung Chou, Chung-Lieh Hung, Cheng-Huang Su, Hung-I Yeh

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Article in Biomarker research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Ting-Yi TienDepartments of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan.
Chiung-Yin ChangDepartments of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan.
Yih-Jer WuDivision of Preventive Cardiology and Pulmonary Circulation Medicine, Department of Cardiovascular Medicine/Cardiovascular Center, MacKay Memorial Hospital, 92, Sec 2, Chung San North Road, Taipei, 10449, Taiwan.
Chao-Feng LinDivision of Preventive Cardiology and Pulmonary Circulation Medicine, Department of Cardiovascular Medicine/Cardiovascular Center, MacKay Memorial Hospital, 92, Sec 2, Chung San North Road, Taipei, 10449, Taiwan.
Yi-Nan LeeDepartments of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan.
Hsin-I LeeInstitute of Clinical Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yen-Hung ChouDepartments of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan.
Chung-Lieh HungDivision of Preventive Cardiology and Pulmonary Circulation Medicine, Department of Cardiovascular Medicine/Cardiovascular Center, MacKay Memorial Hospital, 92, Sec 2, Chung San North Road, Taipei, 10449, Taiwan.
Cheng-Huang SuDivision of Preventive Cardiology and Pulmonary Circulation Medicine, Department of Cardiovascular Medicine/Cardiovascular Center, MacKay Memorial Hospital, 92, Sec 2, Chung San North Road, Taipei, 10449, Taiwan. chsu007@gmail.com.
Hung-I YehDivision of Preventive Cardiology and Pulmonary Circulation Medicine, Department of Cardiovascular Medicine/Cardiovascular Center, MacKay Memorial Hospital, 92, Sec 2, Chung San North Road, Taipei, 10449, Taiwan. hungi.yeh@msa.hinet.net.

Funding

Hung-I Yeh, This work was supported by grants from the National Science Council, and grants from MacKay Memorial Hospital, Taipei, Taiwan. Hung-I Yeh, This work was supported by grants from the NationMOST 110-2314-B-195-025-MY3, MOST 110-2923-B-195-001-MY3, MMH-111-01, MMH-112-01, MMH-113-01
6 · The paper itself

Abstract

backgroundUpregulation of Pannexin 1 (Panx1) has been reported in senescent human endothelial colony-forming cells. We examined whether Panx1 served as a potential biomarker of senescence in peripheral blood mononuclear cells (PBMCs) expressing progenitor markers and its association with inflammation, nitric oxide (NO), and cardiovascular risk.

methodsPanx1 transcripts were assessed in PBMCs from 60 non-diabetic donors (20 aged 20-30 years and 40 aged ≥ 65 years). ECFCs were examined for Panx1-NO interaction. A separate flow-cytometry cohort comprised 50 donors (25 young and 25 elderly) targeting CD34

resultsHigher Panx1 transcript levels existed in PBMCs of the elderly versus young donors. Among the elderly, higher Panx1 transcript levels existed in those respectively with increased fasting glucose (> 100 versus 100 mg/dL) and moderate-to-high FRS (versus low FRS). Panx1 interacted with NO in ECFCs. The proportion of CD34

conclusionsPanx1 in selected circulating progenitor-cell populations is associated with cellular senescence and cardiovascular risk in non-diabetic elderly individuals. Panx1 as a candidate cellular senescence-associated biomarker requires prospective validation.

Indexed as

agingcellular senescencecirculating progenitor cellsFramingham Risk ScorePannexin 1

Identifiers

PMID42855730

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