Evidence map›Paper›PMID 42855713›Full record

ArticleTrials2026

Advantage of cerebellar intermittent theta-burst stimulation in Alzheimer's disease (ACT-AD): study protocol for a multicenter, randomized, double-blind, sham-controlled trial.

Xin Zhang, Wen Li, Zhongqing Sun, Xiaomu Wang, Changgeng Song, Xiaorui Wang, Yinuo Niu, Dong Wei, Wei Zhang, Gejuan Zhang and 5 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Publisher
In one paragraph

Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06669182 (Effects of Cerebellar Transcranial Magnetic Stimulation on Patients With Alzheimer's Disease：A Multicenter Randomized Controlled Trial), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06669182 narecruitingnot on this map

Effects of Cerebellar Transcranial Magnetic Stimulation on Patients With Alzheimer's Disease：A Multicenter Randomized Controlled Trial

TypeinterventionalSponsorXijing HospitalRan2025 to 2026Enrolled100ConditionsAlzheimer Disease, Transcranial Magnetic Stimulation, CerebellumArmsIntermittent Theta-Burst Transcranial Magnetic Stimulation
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xin ZhangDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Wen LiDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Zhongqing SunDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Xiaomu WangDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Changgeng SongDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Xiaorui WangDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Yinuo NiuDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Dong WeiDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Wei ZhangDepartment of Neurology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, 710038, China.
Gejuan ZhangDepartment of Neurology, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, Shaanxi Province, 710000, China.
Bei ZhangDepartment of Neurology, The First Affiliated Hospital of Xi'an Medical University, Xi'an, 710077, China.
Ling WangDepartment of Health Statistics, Fourth Military Medical University, Xi'an, 710032, China.
Zhirong LiuDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Jingjing ZhaoDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. zhaojing0110@126.com.
Wen JiangDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. jiangwen@fmmu.edu.cn.ORCID https://orcid.org/0000-0003-0612-2917

Funding

Clinical Research Program of the Fourth Military Medical University 2024LC2419
6 · The paper itself

Abstract

introductionThe cerebellum plays a crucial role in cognitive processing and thus presents a promising therapeutic target for Alzheimer's disease (AD). This trial aims to evaluate the efficacy and safety of long-term, neuronavigated cerebellar intermittent theta burst stimulation (iTBS) in patients with AD. METHODS AND ANALYSIS: The ACT-AD trial is a multicenter, randomized, double-blind, sham-controlled study involving 100 participants with mild-to-moderate AD across 4 centers in China. Participants will be randomized to receive either cerebellar iTBS or sham stimulation for 4 weeks (daily sessions), followed by 8 weeks of weekly maintenance sessions. The primary outcome is the change in the Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) score from baseline to week 12. Secondary outcomes include additional clinical scales. Exploratory outcomes include electroencephalogram (EEG), blood biomarkers and magnetic resonance imaging (MRI). Statistical analysis will follow intention-to-treat principles using mixed models for repeated measures (MMRM). DISCUSSION: The ACT-AD trial will assess the efficacy and safety of long-term, neuronavigated cerebellar iTBS in treating patients with mild-to-moderate AD.

trial registrationClinicalTrials.gov, NCT06669182. Registered on 31 October 2024.

Indexed as

Alzheimer DiseaseCerebellumTheta RhythmTranscranial Magnetic StimulationAgedChinaCognitionDouble-Blind MethodElectroencephalographyFemaleHumansMagnetic Resonance ImagingMaleMulticenter Studies as TopicRandomized Controlled Trials as TopicTime FactorsAlzheimer’s diseaseCerebellumTheta burst stimulationTranscranial magnetic stimulation

Identifiers

PMID42855713

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.