Evidence map›Paper›PMID 42855710›Full record

ArticleActa neuropathologica communications2026

Altered oligodendroglial cell development and increased myelination in SCN2A gain-of-function-linked epilepsy.

Constanza Bravo-Rossainz Baez, Xian Xin, Hang Lyu, Daniil Kirianov, Ying Sun, Erik Späte, Mariapia Grassia, Birgit Engeland, Malte Stockebrand, Konstantin Khodosevich and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Acta neuropathologica communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Constanza Bravo-Rossainz BaezDepartment of Neurophysiology, Institute of Physiology, University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0009-0008-6825-0328
Xian Xin *Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-1460-5978
Hang Lyu *Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tübingen, Germany.
Daniil Kirianov *Deutsches Zentrum Für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.ORCID http://orcid.org/0009-0001-9971-3718
Ying SunDepartment of Neurophysiology, Institute of Physiology, University of Tübingen, Tübingen, Germany.
Erik SpäteWerner Reichardt Centre for Integrative Neuroscience, University of Tübingen, Tübingen, Germany.
Mariapia GrassiaDepartment of Neurophysiology, Institute of Physiology, University of Tübingen, Tübingen, Germany.
Birgit EngelandDeutsches Zentrum Für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0001-9104-7194
Malte StockebrandDeutsches Zentrum Für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0001-9009-137X
Konstantin KhodosevichBiotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-7232-5558
Ulrike B S HedrichDepartment of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tübingen, Germany.ORCID http://orcid.org/0000-0003-3801-1306
Dirk IsbrandtDeutsches Zentrum Für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0002-4720-1016
Friederike PfeifferDepartment of Neurophysiology, Institute of Physiology, University of Tübingen, Tübingen, Germany. friederike.pfeiffer@uni-tuebingen.de.ORCID https://orcid.org/0000-0002-6167-3263

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gain-of-function variants in SCN2A, encoding the voltage-gated sodium channel Na

Indexed as

EpilepsyMyelin SheathNAV1.2 Voltage-Gated Sodium ChannelOligodendrogliaAnimalsMiceMice, TransgenicNAV1.2 Voltage-Gated Sodium ChannelScn2a protein, mouse

Identifiers

PMID42855710

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.