ReviewJournal of translational medicine2026
Polyamine metabolism in ischemia reperfusion injury: common mitochondrial mechanisms and organ-specific differences.
Review in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyamines are essential polycations that play pivotal roles in various cellular processes, including cell proliferation, redox regulation, protein synthesis, and particularly the maintenance of mitochondrial function. During ischemia/reperfusion injury (I/RI), mitochondrial dysfunction emerges as a common mechanism underlying organ damage. This review systematically explores how polyamine metabolism regulates mitochondrial injury in I/RI, focusing on its impact on mitochondrial homeostasis and exacerbating organ damage through the modulation of reactive oxygen species, calcium homeostasis, mitochondrial membrane potential, and mitophagy. By analyzing polyamine metabolic alterations in the heart, kidney, liver, and brain during I/RI, we observe a common metabolic remodeling characterized by enhanced catabolism, while also identifying organ-specific regulatory responses. Finally, we summarize the potential intervention strategies targeting polyamine metabolism and discuss their translational prospects, offering new insights into therapeutic approaches for I/RI.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.