Evidence map›Paper›PMID 42855673›Full record

ArticleMolecular medicine (Cambridge, Mass.)2026

CD248 expression in human adipose tissue is upregulated in obesity and following glucocorticoid exposure: a mediator of insulin resistance and adipose dysfunction?

Rutger Laterveer, Martin H Lundqvist, Edward M Conway, Afshan N Malik, Maria K Svensson, Magnus Sundbom, Petros Katsogiannos, Jan W Eriksson, Maria J Pereira

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Article in Molecular medicine (Cambridge, Mass.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Rutger LaterveerDepartment of Medical Sciences, Clinical Diabetology and Metabolism, Uppsala University, Uppsala, 751 85, Sweden.
Martin H LundqvistDepartment of Medical Sciences, Clinical Diabetology and Metabolism, Uppsala University, Uppsala, 751 85, Sweden.
Edward M ConwayCentre for Blood Research, Life Sciences Institute, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Afshan N MalikDiabetes & Obesity, School of Cardiovascular Medicine and Metabolic Sciences, King's College London, London, UK.
Maria K SvenssonDepartment of Medical Sciences, Renal Medicine, Uppsala University, Uppsala, Sweden.
Magnus SundbomDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Petros KatsogiannosDepartment of Medical Sciences, Clinical Diabetology and Metabolism, Uppsala University, Uppsala, 751 85, Sweden.
Jan W ErikssonDepartment of Medical Sciences, Clinical Diabetology and Metabolism, Uppsala University, Uppsala, 751 85, Sweden.
Maria J PereiraDepartment of Medical Sciences, Clinical Diabetology and Metabolism, Uppsala University, Uppsala, 751 85, Sweden. maria.pereira@medsci.uu.se.ORCID http://orcid.org/0000-0001-5498-3899

Funding

European Union's Horizon Europe Research and Innovation Action (RIA) project PAS GRAS 101080329the Novo Nordisk Foundation NNF23OC0084483, NNF25OC0101843the Swedish Diabetes Foundation DIA2021-661, DIA2024-935the Swedish Foundation for Strategic Research CMP22-0014the Swedish Research Council 2024-03344
6 · The paper itself

Abstract

backgroundCD248 is a transmembrane glycoprotein implicated in fibrosis, hypoxia, and insulin resistance, but its role in human adipose tissue remains incompletely understood. Because glucocorticoids regulate these processes, we investigated whether CD248 is glucocorticoid responsive and characterized its expression across adipose depots and sexes in obesity.

methodsCD248 expression was assessed in adipose tissue obtained by needle biopsy (75 male/114 female, BMI: 20.1-47.9 kg/m

resultsCD248 expression was higher in subcutaneous adipose tissue in obesity at mRNA (86%) and protein (2-fold) levels, with BMI as the strongest independent predictor. Expression did not differ between individuals with and without type 2 diabetes. Depot-specific differences were identified, with lower CD248 expression in omental adipose tissue than subcutaneous adipose tissue and opposing BMI associations. Sex-specific differences were observed at the protein level, with higher CD248 abundance in females with obesity. Transcriptomic analysis identified remodelling-related pathways in subcutaneous adipose tissue and metabolic pathways in omental adipose tissue. Dexamethasone and cortisol increased CD248 gene expression, and dexamethasone increased CD248 unglycosylated protein in adipocytes. Circulating CD248 increased with BMI and was higher in females with obesity, mirroring adipose tissue protein.

conclusionOur findings identify CD248 as a glucocorticoid-responsive and depot-specific marker associated with adiposity and metabolic disturbances, suggesting a potential role in obesity-related adipose tissue dysfunction.

Indexed as

Adipose TissueAntigens, CDAntigens, NeoplasmGlucocorticoidsInsulin ResistanceObesityAdipocytesAdultAgedBiomarkersDexamethasoneDiabetes Mellitus, Type 2FemaleGene Expression RegulationHumansMaleAntigens, CDAntigens, NeoplasmBiomarkersCD248 protein, humanDexamethasoneGlucocorticoidsAdipose tissueCD248EndosialinGlucocorticoidsInsulin resistanceObesity

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PMID42855673

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