Evidence map›Paper›PMID 42855514›Full record

ArticleSurgical endoscopy2026

Efficacy of endoscopic submucosal dissection for superficial neoplastic lesions in the ileocecal valve region: a large multi-center comparative study.

Kasenee Tiankanon, Joo Ha Hwang, Mohamed O Othman, David L Diehl, Rinrada Worapongpaiboon, Edward John Despott, Yasutoshi Shiratori, Manol Jovani, Anand Kumar, Yutaka Tomizawa and 22 more

Abstract read
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In one paragraph

Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Kasenee TiankanonDivision of Gastroenterology and Hepatology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-8550-8142
Joo Ha HwangDivision of Gastroenterology and Hepatology, Stanford University, Stanford, CA, USA.
Mohamed O OthmanGastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX, USA.
David L DiehlDepartment of Gastroenterology, Geisinger Medical Center, Danville, PA, USA.
Rinrada WorapongpaiboonDivision of Gastroenterology and Hepatology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Edward John DespottRoyal Free Unit for Endoscopy, Royal Free London NHS Foundation Trust, Pond Street, London, UK.
Yasutoshi ShiratoriGastroHealth Florida, Baptist Hospital, Florida International University, Miami, FL, USA.
Manol JovaniGastroHealth Florida, Baptist Hospital, Florida International University, Miami, FL, USA.
Anand KumarDivision of Gastroenterology and Hepatology, Thomas Jefferson University, Philadelphia, PA, USA.
Yutaka TomizawaDivision of Gastroenterology, Harborview Medical Center, University of Washington, Seattle, USA.
Shaimaa ElkholyGastroenterology Division, Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mohammad BilalDivision of Gastroenterology & Hepatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Makoto NishimuraGastroenterology, Hepatology, and Nutrition Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sayaka NagaoGastroenterology, Hepatology, and Nutrition Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Abel JosephDivision of Gastroenterology and Hepatology, Stanford University, Stanford, CA, USA.
Shai FriedlandDivision of Gastroenterology and Hepatology, Stanford University, Stanford, CA, USA.
Mai Ahmed KhalafGastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX, USA.
Molham AbdulsamadDepartment of Gastroenterology, Geisinger Medical Center, Danville, PA, USA.
Georgios KalopitasRoyal Free Unit for Endoscopy, Royal Free London NHS Foundation Trust, Pond Street, London, UK.
Elisabet Maristany BoschRoyal Free Unit for Endoscopy, Royal Free London NHS Foundation Trust, Pond Street, London, UK.
Syed Matthew KodilinyeDepartment of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA.
Daryl RamaiDivision of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Abdulrahman QatomahDivision of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Kevan JosloffDivision of Gastroenterology and Hepatology, Thomas Jefferson University, Philadelphia, PA, USA.
Mohammed El-SherbinyGastroenterology Division, Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Karim EssamGastroenterology Division, Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Hany HaggagGastroenterology Division, Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Abeer AbdellatefGastroenterology Division, Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Kerolis YousefGastroenterology Division, Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mohamed Abdel ZaherMBBCh, Faculty of Medicine, Cairo University, Cairo, Egypt.
Hiroyuki AiharaDivision of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Saowanee NgamruengphongDivision of Gastroenterology and Hepatology, Johns Hopkins Medical Institutions, Baltimore, MD, USA. sngamru1@jhmi.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsEndoscopic submucosal dissection (ESD) of ileocecal valve (ICV) polyps potentially offers higher en bloc resection and lower recurrent rates than endoscopic mucosal resection. However, evidence regarding safety and efficacy of ICV polyp ESD compared to non-ICV polyps remain limited. We aim to assess the safety and efficacy of ICV polyps ESD versus polyps in the right colon.

methodsA multi-center, retrospective cohort study was conducted at 11 referral centers. Polyps in the proximal right-sided colon treated by ESD were included and categorized into ICV and non-ICV group. The primary outcomes were en bloc, R0, curative resection rate. The secondary outcomes were procedural time, adverse event, and local recurrence rates.

resultsA total of 414 patients (age 65.6 ± 11.3 years, 51.7% male) were enrolled (76 ICV and 338 non-ICV). The overall mean polyp size was 37 ± 19 mm. The mean ICV circumferential involvement was 35 ± 23%, with 3(3.9%) lesions with ileal extension. Complete resection rate was comparable between groups (100% vs 99.7%; p = 0.86). ICV group showed lower en bloc (82% vs 93%, p = 0.004), R0 (74% vs 86%, p = 0.001), curative resection rate (74% vs 86%, p = 0.021), and higher post-procedural bleeding rate (9.2% vs 2.7%; p = 0.003). Local recurrence rates were similar (8% vs 6%; p = 0.75), with 90% of recurrences treated endoscopically.

conclusionESD of ICV polyps in expert hands is safe with high rate of complete resection. Despite a lower en bloc resection and higher post-ESD bleeding rate compared to non-ICV polyps, ESD remains an alternative option for large ICV polyps.

Indexed as

ColonColonic polypsColonoscopyEndoscopic submucosal dissectionIleocecal valveOrgan preservation

Identifiers

PMID42855514

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.