Evidence map›Paper›PMID 42855511›Full record

ArticleSurgical endoscopy2026

Preoperative diabetes status, circulating GDF15, and weight loss after sleeve gastrectomy.

Yu-Yang Lee, Young-Jen Lin, Wei-Shiung Yang, Po-Chu Lee, Chiung-Nien Chen, Ming-Tsan Lin, Po-Jen Yang

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Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yu-Yang Lee *Department of Surgery, National Taiwan University Hospital, No.7, Chung Shan S. Rd., Zhongzheng District, Taipei, 100, Taiwan.
Young-Jen Lin *Department of Surgery, National Taiwan University Hospital, No.7, Chung Shan S. Rd., Zhongzheng District, Taipei, 100, Taiwan.
Wei-Shiung YangCenter for Obesity, Life Style, and Metabolic Surgery, National Taiwan University Hospital, No.7, Chung Shan S. Rd., Zhongzheng District, Taipei, 100, Taiwan.
Po-Chu LeeDepartment of Surgery, National Taiwan University Hospital, No.7, Chung Shan S. Rd., Zhongzheng District, Taipei, 100, Taiwan.
Chiung-Nien ChenDepartment of Surgery, National Taiwan University Hospital, No.7, Chung Shan S. Rd., Zhongzheng District, Taipei, 100, Taiwan.
Ming-Tsan LinDepartment of Surgery, National Taiwan University Hospital, No.7, Chung Shan S. Rd., Zhongzheng District, Taipei, 100, Taiwan.
Po-Jen YangDepartment of Surgery, National Taiwan University Hospital, No.7, Chung Shan S. Rd., Zhongzheng District, Taipei, 100, Taiwan. paulpjyang@ntuh.gov.tw.ORCID http://orcid.org/0000-0001-7247-916X

Funding

Taiwan Health Foundation THF 2024001
6 · The paper itself

Abstract

backgroundGrowth differentiation factor 15 (GDF15) is a stress-responsive cytokine implicated in metabolic stress, appetite regulation, and energy homeostasis. However, longitudinal GDF15 changes after metabolic bariatric surgery remain inconsistent, and whether preoperative type 2 diabetes (T2D) modifies postoperative GDF15 trajectories after sleeve gastrectomy (SG) is unclear.

methodsIn this prospective, single-center observational cohort, 105 patients with severe obesity undergoing laparoscopic SG between 2018 and 2022 were studied. Circulating GDF15 and clinical variables were measured preoperatively and at 6 months and 1 year after SG. Patients were stratified by preoperative T2D status. Associations between baseline GDF15 and 1-year total weight loss percentage (TWL%) were assessed using stepwise multivariable linear regression.

resultsParticipants were 53 males, mean age 39.3 ± 10.4 years, and BMI 40.4 ± 5.4 kg/m

conclusionsAfter SG, circulating GDF15 follows distinct trajectories according to preoperative T2D status. Baseline GDF15 may help characterize individual variability in metabolic adaptation and weight loss after SG.

Indexed as

Bariatric surgeryDiabetesGrowth differentiation factor 15ObesitySleeve gastrectomyWeight loss

Identifiers

PMID42855511

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.