Evidence map›Paper›PMID 42854667›Full record

ArticleJACC. Basic to translational science2026

Identifying Cardiac Autoantibody Biomarkers that Predict the Severity of Chagas Cardiomyopathy.

Heriks Ribeiro, Anton Dmitriev, Antonia Pereira Rosa Neta, Meena Fatah, Diptendu Chatterjee, Lea Campos de Oliveira, Fabiano Castro Albrecht, Hui Tzu Lin Wang, Juliana de Assis S Gomes, Olgierd Woźniak and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Heriks RibeiroDepartment of Clinical Analysis and Toxicology, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Department of Pediatrics, The Labatt Family Heart Centre and Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Anton DmitrievDepartment of Pediatrics, The Labatt Family Heart Centre and Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Antonia Pereira Rosa NetaDepartment of Clinical Analysis and Toxicology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Meena FatahDepartment of Pediatrics, The Labatt Family Heart Centre and Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Diptendu ChatterjeeDepartment of Pediatrics, The Labatt Family Heart Centre and Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Lea Campos de OliveiraDepartment of Infectious Disease, Tropical Medicine, University of São Paulo, São Paulo, SP, Brazil.
Fabiano Castro AlbrechtDante Pazzanese Institute of Cardiology, São Paulo, SP, Brazil.
Hui Tzu Lin WangDante Pazzanese Institute of Cardiology, São Paulo, SP, Brazil.
Juliana de Assis S GomesDepartment of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Olgierd WoźniakDepartment of Congenital Heart Diseases, Cardinal Stefan Wyszyński National Institute of Cardiology, Warsaw, Poland.
Karolina BorowiecDepartment of Congenital Heart Diseases, Cardinal Stefan Wyszyński National Institute of Cardiology, Warsaw, Poland.
Elżbieta Katarzyna BiernackaDepartment of Congenital Heart Diseases, Cardinal Stefan Wyszyński National Institute of Cardiology, Warsaw, Poland.
Antonia Claudia Jácome da CâmaraDepartment of Clinical Analysis and Toxicology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Luciana SacilottoArrhythmia Unit, Heart Institute (Institute Coração), University of São Paulo Medical School, São Paulo, Brazil.
Francisco Carlos da Costa DarrieuxArrhythmia Unit, Heart Institute (Institute Coração), University of São Paulo Medical School, São Paulo, Brazil.
Maurício Ibrahim ScanavaccaArrhythmia Unit, Heart Institute (Institute Coração), University of São Paulo Medical School, São Paulo, Brazil.
José Eduardo KriegerLaboratory of Genetics and Molecular Cardiology (LGMC), Heart Institute (Institute Coração), University of São Paulo Medical School, São Paulo, Brazil.
Lúcia Maria da Cunha GalvãoDepartment of Clinical Analysis and Toxicology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Walderez DutraDepartment of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Antonio Luiz Pinho RibeiroDepartment of Internal Medicine, School of Medicine, Telehealth Center, Cardiology Service, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Edecio Cunha-NetoLaboratory of Clinical Immunology and Allergy, Heart Institute (InCor), Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; Institute of Investigation in Immunology, National Institute of Science and Technology (iii-INCT), São Paulo, Brazil.
Maria Carmo Pereira NunesDepartment of Internal Medicine, School of Medicine, Telehealth Center, Cardiology Service, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Ester Cerdeira SabinoDepartment of Infectious Disease, Tropical Medicine, University of São Paulo, São Paulo, SP, Brazil.
Igor CestariInstitute of Parasitology, McGill University, Sainte-Anne-de-Bellevue, Quebec, Canada; Division of Clinical and Translational Research, Department of Medicine, McGill University, Montreal, Quebec, Canada.
Andre Ducati LuchessiDepartment of Clinical Analysis and Toxicology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Vivian Nogueira SilbigerDepartment of Clinical Analysis and Toxicology, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Department of Pediatrics, The Labatt Family Heart Centre and Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address: vivian.silbiger@sickkids.ca.
Robert M HamiltonDepartment of Pediatrics, The Labatt Family Heart Centre and Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address: robert.hamilton@sickkids.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chagas cardiomyopathy (ChCM) affects up to 30% of patients with chronic Chagas disease and lacks reliable biomarkers for severity and conduction abnormalities. We profiled cardiac autoantibodies using 2-dimensional gel electrophoresis and mass spectrometry, followed by enzyme-linked immunosorbent assay validation and machine learning analysis. Six autoantibodies linked to glycolysis, adenosine triphosphate metabolism, and sarcomere structure distinguished ChCM stages (area under the curve: 0.87; 95% CI: 0.777-0.977) and a mean classification accuracy (0.84; 95% CI: 0.705-0.935). These findings suggest that an antibody-based panel may enable cost-effective risk stratification and prognostication in ChCM, with prospective validation before clinical application.

Indexed as

autoantibodiesbiomarkersChagas cardiomyopathyChagas diseasedisease severityELISA

Identifiers

PMID42854667
PMCPMC13677190

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.