Evidence map›Paper›PMID 42854177›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2026

Detection of MOG-IgG and MOG-IgA in Maternal Breast Milk and Infant Blood in MOGAD: A Case Report.

Masoud Majed, Fatemeh Khani-Habibabadi, Anjali J Panicker, Sarah Reasbeck, Christopher Orlando, Jeffrey Gluckstein, Scott S Zamvil, Lilyana Amezcua, Kevin C O'Connor

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. MOG Antibody in Pregnancy and Breast Milk: An Analysis of 2 Case Reports.Neurology(R) neuroimmunology & neuroinflammation · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Masoud MajedDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles.
Fatemeh Khani-HabibabadiDepartments of Neurology and Immunobiology, Yale School of Medicine, Yale University, New Haven, CT.ORCID 0000-0003-3790-4946
Anjali J PanickerDepartments of Neurology and Immunobiology, Yale School of Medicine, Yale University, New Haven, CT.ORCID 0000-0001-6953-966X
Sarah ReasbeckDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles.
Christopher OrlandoDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles.ORCID 0000-0001-9357-7076
Jeffrey GlucksteinDepartment of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles.ORCID 0000-0002-6034-0096
Scott S ZamvilDepartment of Neurology & Weill Institute for Neurosciences, University of California, San Francisco; and.ORCID 0000-0003-2720-9915
Lilyana AmezcuaDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles.ORCID 0000-0003-1542-7819
Kevin C O'ConnorDepartments of Neurology and Immunobiology, Yale School of Medicine, Yale University, New Haven, CT.ORCID 0000-0002-7056-419X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesMyelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an inflammatory demyelinating disorder of the CNS characterized by pathogenic MOG autoantibodies. Data regarding maternal-infant transfer of MOG autoantibodies, particularly in breast milk, are limited. We aimed to characterize maternal MOG autoantibodies longitudinally and assess their presence in maternal plasma, breast milk, and infant blood, as well as their clinical relevance in the infant.

methodsMOG-specific IgG, IgA, and IgM, including selected subclass analyses, were assessed by cell-based assays in longitudinal maternal plasma and breast milk samples, as well as infant plasma at birth. Additional assays assessed epitope specificity and isoform recognition.

resultsMaternal plasma MOG-IgG titers were persistently elevated, with transient reduction during early pregnancy. MOG-IgG and MOG-IgA were detected in maternal plasma and breast milk. Binding patterns to MOG isoforms and epitopes were near-identical between compartments and restricted to the IgG1 and IgA1 subclasses. The infant tested positive for MOG-IgG at birth. The infant remained clinically asymptomatic through 18 months, despite autoantibody detection and ongoing breastfeeding. DISCUSSION: Maternal MOG autoantibodies in blood and breast milk were not associated with clinical disease in the infant, suggesting no increased risk of MOGAD from maternal transmission.

Indexed as

AutoantibodiesImmunoglobulin AImmunoglobulin GMilk, HumanMyelin-Oligodendrocyte GlycoproteinMyelin Oligodendrocyte Glycoprotein Antibody-Associated DiseaseAdultFemaleHumansInfant, NewbornPregnancyAutoantibodiesImmunoglobulin AImmunoglobulin GMOG protein, humanMyelin-Oligodendrocyte Glycoprotein

Identifiers

PMID42854177
PMCPMC13676278

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