Evidence map›Paper›PMID 42854023›Full record

ArticleMedicine2026

Relapsed/refractory PBML complicated with failed platelet implantation and mixed infection after allo-HSCT: A case report.

Ying He, Fangyi Fan, Yingling Zhou, Wei Sun, Guangcui He, Yan Deng, Hai Yi

Abstract readCase Reports
In one paragraph

Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ying HeDepartment of Hematology, Chinese People's Liberation Army The General Hospital of Western Theater Command, Chengdu, Sichuan, China.ORCID 0009-0002-3615-4098
Fangyi FanDepartment of Hematology, Chinese People's Liberation Army The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Yingling ZhouDepartment of Emergency Medicine, Chinese People's Liberation Army The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Wei SunDepartment of Laboratory Medicine, Chinese People's Liberation Army The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Guangcui HeDepartment of Hematology, Chinese People's Liberation Army The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Yan DengDepartment of Hematology, Chinese People's Liberation Army The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Hai YiDepartment of Hematology, Chinese People's Liberation Army The General Hospital of Western Theater Command, Chengdu, Sichuan, China.ORCID 0000-0003-3794-266

Funding

High-quality Specialized of the Joint Logistic Support Force 41C41B27
6 · The paper itself

Abstract

rationalePrimary bone marrow lymphoma (PBML) is a rare lymphoma with a poor prognosis, characterized by tumor origin restricted to the bone marrow. Diffuse large B-cell lymphoma (DLBCL) is its most common subtype. PATIENT CONCERNS: We report a case of a 48-year-old female with refractory non-germinal center DLBCL originating in the bone marrow, accompanied by p53 overexpression, complex karyotype, and hemophagocytic lymphohistiocytosis. DIAGNOSES: Given the aforementioned adverse genetic features, together with primary platelet poor graft function following allogeneic hematopoietic stem cell transplantation (allo-HSCT), mixed infections, severe acute intestinal graft-versus-host disease (GVHD), and progressive bone marrow stromal necrosis, the patient was diagnosed with multifactorial post-transplant poor graft function with bone marrow microenvironment injury.

interventionsThe patient received induction chemotherapy and achieved complete remission, followed by autologous-hematopoietic stem cell transplantation (autoHSCT) for consolidation. After relapse within 3 months, salvage therapy and subsequent allogeneic-hematopoietic stem cell transplantation were performed. OUTCOMES: Despite intensive supportive therapy, the patient died from massive gastrointestinal bleeding. A literature review identified this as a rare case of PBML with primary platelet Poor graft function and mixed infections post-allo-HSCT. LESSONS: This case highlights the treatment challenges and extremely poor prognosis in ultrahigh-risk PBML with adverse genetic features and severe post-transplant complications.

Indexed as

Hematopoietic Stem Cell TransplantationLymphoma, Large B-Cell, DiffusePlatelet TransfusionFatal OutcomeFemaleGraft vs Host DiseaseHumansMiddle AgedRecurrenceTransplantation, Homologousallogeneic hematopoietic stem cell transplantationcase reportmixed infectionprimary bone marrow lymphomaprimary platelet engraftment failure

Identifiers

PMID42854023
PMCPMC13657572

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.