Evidence map›Paper›PMID 42853952›Full record

ArticleScience advances2026

A neuronal GPCR modifies neuropeptide signaling to suppress proteostasis in distal tissues.

Joud Hirbawi, Adam Zaretsky, Huadong Zhu, Uri Goshtchevsky, Gourab Dey, Emmanuelle Merquiol, Atif Ahmed Siddiqui, Irit Cohen, Galia Blum, Ehud Cohen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joud HirbawiDepartment of Biochemistry and Molecular Biology, the Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID 0009-0004-9023-8158
Adam ZaretskyDepartment of Biochemistry and Molecular Biology, the Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID 0009-0001-0323-0413
Huadong ZhuDepartment of Biochemistry and Molecular Biology, the Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.
Uri GoshtchevskyDepartment of Biochemistry and Molecular Biology, the Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.
Gourab DeyInstitute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University, Jerusalem, Israel.ORCID 0000-0002-9570-5032
Emmanuelle MerquiolInstitute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University, Jerusalem, Israel.ORCID 0000-0001-5754-498X
Atif Ahmed SiddiquiDepartment of Biochemistry and Molecular Biology, the Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.
Irit CohenDepartment of Biochemistry and Molecular Biology, the Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.
Galia BlumInstitute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University, Jerusalem, Israel.ORCID 0000-0002-9374-2489
Ehud CohenDepartment of Biochemistry and Molecular Biology, the Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID 0000-0001-5552-7086

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The proteostasis network (PN) safeguards the integrity of proteins by promoting various cellular activities. However, with aging, the PN's competence declines and aggregated proteins accrue within cells. This process underlies the development of neurodegenerative disorders such as Alzheimer's and Huntington's diseases. While the PN functions within cells, proteostasis is regulated across the organism by intertissue communication, which is partially governed by neurons. We previously found that reducing the expression of

Indexed as

Caenorhabditis elegans ProteinsNeuronsNeuropeptidesProteostasisReceptors, G-Protein-CoupledSignal TransductionAnimalsCaenorhabditis elegansGene Knockdown TechniquesProteolysisCaenorhabditis elegans ProteinsNeuropeptidesReceptors, G-Protein-Coupled

Identifiers

PMID42853952
PMCPMC13651884

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.