ArticleScience advances2026
A helix-loop-helix gene orchestrates male fate in common carp.
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40 authors.
Kuangxin ChenState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0009-0009-1822-5535
Ji ChenState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0000-0003-1468-3925
Miao DingState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0000-0003-2111-7913
Yi RongState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0009-0004-2424-9932
Yuanqi GuoState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0009-0005-0486-0854
Yongming LiState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0009-0009-2019-9647
Binbin TaoState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0000-0002-8187-7052
Yanlong SongState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0000-0002-6012-4457
Xingxing WuState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0009-0009-2983-0159
Lei ChenState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0009-0003-5568-0322
Rui LiState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0000-0002-4434-2120
Mouyan JiangState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0009-0001-3147-532X
Zhaoxian LiState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0009-0007-5514-1539
Shaoting JiaState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0009-0002-7493-0799
Yunya WuState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0009-0004-9414-2145
Yulai WeiState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0009-0002-6555-7646
Yinjun JiangState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0000-0001-8890-743X
Hairong LiuState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0000-0002-6458-1786
Shuhui JiState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0009-0008-6786-773X
Wenge MaState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0000-0001-9928-0214
Xishuang ShanState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0009-0007-3717-4249
Wenrong ZhongState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0009-0001-0992-845X
Wen XuState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0009-0001-8558-4281
Xianyao LiaoState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0009-0006-7570-5509
Lu ChenState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0000-0002-3830-3299
Xiya ZhangState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0009-0004-1053-9509
Junzhi LuoState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0009-0006-9884-3912
Xuefan CuiState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0000-0001-5468-0388
Hongrui LuoState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0009-0006-6597-4000
Fei LiuState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0000-0002-0310-1072
Houpeng WangState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0000-0002-7462-6562
Zhixian QiaoState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0000-0002-0154-2317
Xiaocui ChaiState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0009-0006-5023-1650
Fang ZhouState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0009-0003-4082-248X
Daji LuoState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0000-0002-8051-9624
Shunping HeState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0000-0001-9087-7890
Zuoyan ZhuState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0000-0002-3337-5912
Vance L TrudeauDepartment of Biology, University of Ottawa, Ottawa K1N 6N5, Canada.ORCID 0000-0002-0845-9444
Chutian GeCollege of Biological and Environmental Sciences, Institute of Animal Sex and Development, Zhejiang Wanli University, Ningbo 315100, Zhejiang, China.ORCID 0000-0002-7978-6629
Wei HuState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan 430072, China.ORCID 0000-0002-6475-6427
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fish show exceptional diversity in sex-determination mechanisms, making them a powerful system for studying how these pathways evolve. However, no definitive master sex-determining gene has yet been identified in Cyprinidae, a widely distributed and species-rich fish family. Here, we identified a male-specific gene in common carp encoding Pangu, a helix-loop-helix (HLH) domain peptide localized to Sertoli cells. Loss- and gain-of-function analyses demonstrate that
Indexed as
CarpsFish ProteinsHelix-Loop-Helix MotifsSex Determination ProcessesAmino Acid SequenceAnimalsAromataseFemaleGene Expression Regulation, DevelopmentalMaleSertoli CellsSex DifferentiationTestisAromataseFish Proteins
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