Evidence map›Paper›PMID 42853945›Full record

ArticleScience advances2026

Canonical Wnt induction by OTULIN prevents keratinocyte death and skin inflammation.

Kim Lecomte, Pieter Hertens, Virginie Wylleman, Annagiada Toniolo, Febe Roelandt, Fleur Boone, Maarten Ciers, Lien Verboom, Katrien Staes, Geert van Loo and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kim LecomteVIB Center for Inflammation Research, 9052 Ghent, Belgium.ORCID 0000-0001-8402-9799
Pieter HertensVIB Center for Inflammation Research, 9052 Ghent, Belgium.ORCID 0000-0002-8994-5224
Virginie WyllemanVIB Center for Inflammation Research, 9052 Ghent, Belgium.ORCID 0009-0006-6445-3000
Annagiada TonioloVIB Center for Inflammation Research, 9052 Ghent, Belgium.ORCID 0000-0001-6332-6225
Febe RoelandtVIB Center for Inflammation Research, 9052 Ghent, Belgium.ORCID 0009-0002-8354-5999
Fleur BooneVIB Center for Inflammation Research, 9052 Ghent, Belgium.ORCID 0000-0002-6492-8401
Maarten CiersVIB Center for Inflammation Research, 9052 Ghent, Belgium.
Lien VerboomVIB Center for Inflammation Research, 9052 Ghent, Belgium.ORCID 0000-0002-1942-4554
Katrien StaesVIB Center for Inflammation Research, 9052 Ghent, Belgium.ORCID 0009-0004-2343-8686
Geert van LooVIB Center for Inflammation Research, 9052 Ghent, Belgium.ORCID 0000-0002-8427-4775
Esther HosteVIB Center for Inflammation Research, 9052 Ghent, Belgium.ORCID 0000-0002-3181-431X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Loss-of-function mutations in the human

Indexed as

EndopeptidasesKeratinocytesSkinWnt Signaling PathwayAnimalsbeta CateninCell DeathDeubiquitinating EnzymesHumansMiceTumor Necrosis Factor-alphaUbiquitinationWnt Proteinsbeta CateninDeubiquitinating EnzymesEndopeptidasesOTULIN protein, humanTumor Necrosis Factor-alphaWnt Proteins

Identifiers

PMID42853945
PMCPMC13651886

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.