Evidence map›Paper›PMID 42853937›Full record

ArticleScience advances2026

Enhancer binding kinetics explain transcription factor hub formation.

Samantha Fallacaro, Manya Kapoor, Lillian Encarnation, Apratim Mukherjee, Meghan A Turner, Hernan G Garcia, Mustafa Mir

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samantha FallacaroDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-7749-0034
Manya KapoorDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-0352-5131
Lillian EncarnationDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0009-0008-6790-0712
Apratim MukherjeeDevelopmental, Stem Cell, and Regenerative Biology Graduate Group, Perelman School of Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0002-1762-3277
Meghan A TurnerBiophysics Graduate Group, University of California at Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0003-2451-5036
Hernan G GarciaBiophysics Graduate Group, University of California at Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-5212-3649
Mustafa MirDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-8280-2821

Funding

Quantifying the dynamics of gene regulation and nuclear organization during embryogenesisDP2HD108775 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI MIR, MUSTAFA AIZED HASAN · 2021 to 2024
$2.6M
Predictive understanding of the temporal control of transcription in Drosophila developmentR01GM139913 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI GARCIA, HERNAN GUSTAVO · 2021 to 2024
$1.2M
In vivo mechanisms of Dorsal-mediated transcriptional control in developmentR01GM152815 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI GARCIA, HERNAN GUSTAVO · 2024 to 2024
$306k
NICHD NIH HHS DP2 HD108775NIGMS NIH HHS R01 GM139913NIGMS NIH HHS R01 GM152815
6 · The paper itself

Abstract

Transcription factors (TFs) form dynamic, high-concentration clusters, condensates, or hubs, proposed to increase TF binding frequency at target enhancers. However, how enhancer sequence shapes hub properties remains unclear. We developed a live imaging-based framework to quantify the spatiotemporal relationship between TF hubs and actively transcribed genes in live

Indexed as

Drosophila ProteinsEnhancer Elements, GeneticTranscription FactorsAnimalsBinding SitesDNADNA-Binding ProteinsDrosophilaDrosophila melanogasterGene Expression Regulation, DevelopmentalKineticsNuclear ProteinsPhosphoproteinsProtein BindingTranscription, Geneticdl protein, DrosophilaDNADNA-Binding ProteinsDrosophila ProteinsNuclear ProteinsPhosphoproteinsTranscription Factors

Identifiers

PMID42853937
PMCPMC13651869

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.