Evidence map›Paper›PMID 42853930›Full record

ArticleScience advances2026

ALIX-dependent small extracellular vesicles from tissue-resident mesenchymal cells regulate pancreatic β cell proliferation in obesity.

Yuhei Uehara, Hirofumi Nagao, Aoki Tobimatsu, Keitaro Kawada, Shunsuke Shiode, Emi Horitani, Yoshinari Obata, Shiro Fukuda, Yuya Fujishima, Shunbun Kita and 2 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuhei UeharaDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.ORCID 0009-0008-8739-0721
Hirofumi NagaoDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.ORCID 0009-0001-1261-4160
Aoki TobimatsuDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.
Keitaro KawadaDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.ORCID 0000-0003-4976-2121
Shunsuke ShiodeDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.ORCID 0009-0007-7682-0602
Emi HoritaniDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.ORCID 0000-0003-1434-9214
Yoshinari ObataDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.ORCID 0000-0002-3443-3635
Shiro FukudaDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.ORCID 0000-0003-0712-7154
Yuya FujishimaDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.ORCID 0000-0003-0028-1757
Shunbun KitaDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.ORCID 0000-0002-8937-0053
Hitoshi NishizawaDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.
Iichiro ShimomuraDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cells throughout the body release small extracellular vesicles (sEVs), including exosomes, that function as modulators of both local and systemic metabolism. Using mice in which ALIX, a key regulator of sEV biogenesis, was selectively deleted in PDGFRα

Indexed as

Extracellular VesiclesInsulin-Secreting CellsMesenchymal Stem CellsObesityAnimalsCell ProliferationDiet, High-FatGlucoseInsulin ResistanceMaleMiceMice, KnockoutReceptor, Platelet-Derived Growth Factor alphaGlucoseReceptor, Platelet-Derived Growth Factor alpha

Identifiers

PMID42853930
PMCPMC13651848

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.