Evidence map›Paper›PMID 42853914›Full record

ArticleScience advances2026

Influenza A virus infection induces immune dysregulation in the placenta and fetus without vertical transmission in nonhuman primates.

Orlando Cervantes, Sidney Sun, Hazel Huang, Briana Del Rosario, Hong Zhao, Amanda Li, Andrew Vo, Gygeria Manuel, Roslyn Van Abel, Jeff Munson and 24 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

34 authors.

Orlando CervantesDepartment of Global Health, University of Washington, Seattle, WA, USA.ORCID 0000-0003-3187-9567
Sidney SunDepartment of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.ORCID 0009-0003-7254-0401
Hazel HuangDepartment of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.
Briana Del RosarioDepartment of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.
Hong ZhaoDepartment of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.ORCID 0009-0002-0838-8831
Amanda LiDepartment of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.ORCID 0009-0008-4089-3655
Andrew VoDepartment of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.ORCID 0009-0008-2367-6691
Gygeria ManuelDepartment of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-9299-2574
Roslyn Van AbelDepartment of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.
Jeff MunsonDepartment of Psychiatry, University of Washington, Seattle, WA, USA.
John CorneliusDepartment of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.ORCID 0009-0003-6381-9603
Raj P KapurDepartment of Lab Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-5718-407X
Miranda LiDepartment of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.ORCID 0000-0001-7541-3748
Edmunda LiDepartment of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.ORCID 0009-0000-9426-3546
Hanning LiDepartment of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.ORCID 0009-0002-0746-2286
Alexandra ChristodoulouWashington National Biomedical Research Center, Seattle, WA, USA.ORCID 0009-0006-3619-8276
Melissa BergWashington National Biomedical Research Center, Seattle, WA, USA.ORCID 0000-0002-0053-9503
Britni CurtisWashington National Biomedical Research Center, Seattle, WA, USA.ORCID 0009-0002-5824-9856
Elizabeth MillerWashington National Biomedical Research Center, Seattle, WA, USA.ORCID 0009-0000-8864-8538
Shannon RuffWashington National Biomedical Research Center, Seattle, WA, USA.
Brenna MenzWashington National Biomedical Research Center, Seattle, WA, USA.
Solomon WangariWashington National Biomedical Research Center, Seattle, WA, USA.
Audrey GermondWashington National Biomedical Research Center, Seattle, WA, USA.
Audrey BaldessariWashington National Biomedical Research Center, Seattle, WA, USA.ORCID 0000-0001-6392-3230
Chris EnglishWashington National Biomedical Research Center, Seattle, WA, USA.ORCID 0000-0002-7229-3258
W McIntyre DurningWashington National Biomedical Research Center, Seattle, WA, USA.
Thomas B LewisDepartment of Microbiology, University of Washington, Seattle, WA, USA.ORCID 0009-0003-8463-6718
Megan N FredericksDepartment of Microbiology, University of Washington, Seattle, WA, USA.ORCID 0009-0002-8865-9688
Mara MaughanDepartment of Microbiology, University of Washington, Seattle, WA, USA.ORCID 0009-0003-5631-0577
Austyn OrvisCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Michelle ColemanCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.ORCID 0000-0002-6752-3266
Lakshmi RajagopalDepartment of Global Health, University of Washington, Seattle, WA, USA.ORCID 0000-0003-3373-2323
Deborah H FullerWashington National Biomedical Research Center, Seattle, WA, USA.ORCID 0000-0001-7315-2441
Kristina M Adams WaldorfDepartment of Global Health, University of Washington, Seattle, WA, USA.ORCID 0000-0002-6939-7224

Funding

Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
WaNPRC Macaca nemestrina SPF Breeding ColonyU42OD011123 · OD · UNIVERSITY OF WASHINGTON · PI CHARLOTTE HOTCHKISS · 2012 to 2026
$34.4M
University of Washington Medical Scientist Training Program: MD/PhDT32GM007266 · NIGMS · UNIVERSITY OF WASHINGTON · PI HORWITZ, MARSHALL S. · 1985 to 2023
$30.4M
NRSA Training CoreTL1TR002318 · NCATS · UNIVERSITY OF WASHINGTON · PI Megan Moore · 2017 to 2026
$8.4M
Diseases of Public Health Importance Training GrantT32AI007509 · NIAID · UNIVERSITY OF WASHINGTON · PI LUND, JENNIFER M · 1997 to 2024
$6.3M
Influenza pathogenesis in pregnancyR01AI164588 · NIAID · UNIVERSITY OF WASHINGTON · PI ADAMS WALDORF, KRISTINA M. · 2021 to 2025
$4.2M
Impact of Zika Virus Infection on Fetal Innate and Adaptive ImmunityR01AI176777 · NIAID · UNIVERSITY OF WASHINGTON · PI Kristina M. Adams Waldorf · 2024 to 2026
$2.5M
NCATS NIH HHS TL1 TR002318NIAID NIH HHS R01 AI164588NIAID NIH HHS R01 AI176777NIAID NIH HHS T32 AI007509NIGMS NIH HHS T32 GM007266NIH HHS P51 OD010425NIH HHS U42 OD011123
6 · The paper itself

Abstract

Influenza A virus (IAV) infection during pregnancy is associated with stillbirth and preterm birth. We hypothesized that maternal IAV infection disrupts placental and fetal immune networks in ways that correlate with disease severity. Pregnant pigtail macaques were inoculated with IAV [A/California/07/2009 (H1N1)] and underwent delivery and fetal necropsy 5 days postinfection (

Indexed as

FetusInfectious Disease Transmission, VerticalInfluenza A Virus, H1N1 SubtypeOrthomyxoviridae InfectionsPlacentaPregnancy Complications, InfectiousAnimalsFemaleMacaca nemestrinaPregnancyViral Load

Identifiers

PMID42853914
PMCPMC13651839

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.