ArticleProceedings of the National Academy of Sciences of the United States of America2026
A second-generation "hypoxia in a pill" rescues neurodegenerative phenotypes across distinct mouse models.
Hong Wang, Eizo Marutani, Luca Zazzeron, Marissa Menard, Laura Volpicelli-Daley, Fumito Ichinose, Vamsi K Mootha
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors.
Hong WangHHMI and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.
Eizo MarutaniAnesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Luca ZazzeronAnesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Marissa MenardKillion Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294.
Laura Volpicelli-DaleyKillion Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294.
Fumito IchinoseAnesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.ORCID 0000-0003-4535-1632 Vamsi K MoothaHHMI and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.ORCID 0000-0001-9924-642X Funding
Research Training for AnesthetistsT32GM007592 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI STUART A FORMAN · 1985 to 2026
$11.8MPreventing and Reversing Mitochondrial Leigh Syndrome with HypoxiaR01NS124679 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Vamsi Krishna Mootha · 2022 to 2026
$2.6MRole of sulfide catabolism in ischemic brain injuryR01NS112373 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ICHINOSE, FUMITO · 2019 to 2023
$1.7MAbby Mac Foundation N/ADan Garland Memorial Fund N/AFriedreich's Ataxia Research Alliance (FARA) N/AHHMI (HHMI) Investigator AwardHHS | NIH (NIH) R01NS112373HHS | NIH (NIH) R01NS124679HHS | NIH (NIH) T32-GM007592J. Willard and Alice S. Marriott Foundation (Marriott Foundation) N/ANIGMS NIH HHS T32 GM007592NINDS NIH HHS R01 NS112373NINDS NIH HHS R01 NS124679
6 · The paper itselfAbstract
A growing body of preclinical research is demonstrating the therapeutic potential of chronic, continuous hypoxia (11% FIO
Indexed as
HypoxiaNeurodegenerative DiseasesAnimalsBasic Helix-Loop-Helix ProteinsDisease Models, AnimalElectron Transport Complex IEndothelial PAS Domain-Containing Protein 1HemoglobinsMiceMice, KnockoutMitochondrial DiseasesOxygenPhenotypeBasic Helix-Loop-Helix ProteinsElectron Transport Complex IEndothelial PAS Domain-Containing Protein 1HemoglobinsNdufs4 protein, mouseOxygenhemoglobinHIF-2αhyperoxiahypoxianeurodegeneration
Identifiers
PMID42853664
PMCPMC13663714
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