ArticleIndian pediatrics2026
Prediction of Severe Acute Kidney Injury by Positive Renal Angina Index and Cystatin C in Children with Septic Shock: A Diagnostic Accuracy Study.
Article in Indian pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the predictive performance of Renal Angina Index (RAI) for the development of severe acute kidney injury (AKI) in children with septic shock and to compare its performance with serum and urine cystatin C.
methodsThis diagnostic accuracy study enrolled 60 consecutive children admitted to the Pediatric Intensive Care Unit (PICU) with septic shock. The primary outcome was the proportion of children with positive RAI who developed severe AKI within seven days of admission. Secondary outcomes included comparing the performance of RAI with serum and urine cystatin C for early prediction of severe AKI, and evaluating its predictive ability for the need for renal replacement therapy (RRT), mechanical ventilation (MV), and 28-day mortality.
resultsRenal angina index was positive in 29 (48.3%) patients. Positive RAI showed a sensitivity of 81.8% and specificity of 92.6%, with an area under the receiver operating characteristic curve (AUROC) of 0.81(95% CI, 0.69-0.90) for predicting severe AKI. The AUROCs of serum and urine cystatin C were 0.89 (95% CI, 0.86-0.99) and 0.72 (95% CI, 0.60-0.84), respectively. The combination of RAI and serum cystatin C yielded an AUROC of 0.99 (95% CI, 0.98-1.00). The AUROCs of RAI for predicting need for RRT, MV, and mortality were 0.84 (95% CI, 0.71-0.96), 0.73 (95% CI, 0.59-0.86) and 0.74 (95% CI, 0.58-0.89), respectively.
conclusionRenal angina index has good accuracy for predicting severe AKI within seven days of admission in children presenting with septic shock. RAI combined with serum cystatin C provides better predictability for severe AKI.
Indexed as
Identifiers
42853503What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.