ArticleInfection2026
Retrospective two-centre study of human tularemia, Austria.
Article in Infection, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
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Abstract
purposeTularemia, a zoonotic bacterial infection has re-emerged in many European countries over the last years. Data on the management of tularemia are scarce.
methodsIn this two-centre retrospective cohort study, we describe real-world data on the clinical manifestations, diagnostic procedures and management of 51 tularemia patients in East Austria.
resultsThe patients showed heterogeneous clinical presentation, including glandular infection (n = 17, 33.3%), ulceroglandular infection (n = 23, 45.1%), pulmonary infection (n = 10, 19.6%) and typhoidal infection (n = 1, 2%). Notably, seven cases were culture positive, including one case with positive blood culture. Time to achieve the correct diagnosis was associated with the duration of treatment (β = 0.89, p < 0.001), as well as the need for a surgical intervention (OR 1.04, 95%CI 1.01-1.09, p = 0.04). Moreover, we demonstrate a high rate of treatment failure in patients receiving monotherapy (27%).
conclusionWe highlight the heterogeneous clinical presentation of tularemia patients in Austria. Further we demonstrate that timely diagnosis and a prompt implementation of an appropriate antimicrobial therapy may contribute to shorter treatment durations and a reduced need for surgical intervention.
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