ArticleSurgical and radiologic anatomy : SRA2026
Quadrant-specific anatomical architecture of the peripapillary retinal nerve fiber layer: a spectral-domain optical coherence tomography study.
Article in Surgical and radiologic anatomy : SRA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate the quadrant-specific anatomical organization of the peripapillary retinal nerve fiber layer (RNFL) and identify the independent determinants of global RNFL thickness in healthy adults using spectral-domain optical coherence tomography (SD-OCT).
methodsThis retrospective cross-sectional study included 188 healthy adults (18-76 years). Medical records containing SD-OCT-derived peripapillary RNFL and optic nerve head measurements were reviewed retrospectively. Only right eyes were analyzed to avoid inter-eye correlation. Quadrant-specific RNFL differences were evaluated using the Friedman test with Bonferroni-adjusted pairwise comparisons. Associations with age, spherical equivalent, and neuroretinal rim area were examined using Spearman's correlation, followed by multiple linear regression analysis.
resultsMean global RNFL thickness was 107.86 ± 8.97 μm. RNFL thickness followed the ISNT pattern (inferior > superior > nasal > temporal). Quadrant differences were significant (χ
conclusionIn healthy adults, peripapillary RNFL thickness exhibits a highly organized anatomical architecture characterized by the ISNT pattern, consistent with the topographic organization of retinal ganglion cell axons around the optic nerve head. OCT-derived RNFL measurements should therefore be interpreted in the context of age, refractive status, and neuroretinal rim area.
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