ArticleOphthalmology and therapy2026
Characteristics and Factors of Incision-Related Descemet Membrane Detachment During Cataract Surgery: A Prospective Study.
Article in Ophthalmology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionIncision-related Descemet membrane detachment (DMD) can arise at different stages of cataract surgery, but its real-time intraoperative characteristics and associated factors remain incompletely understood. This study aimed to characterize incision-related DMD in 2.65 mm clear corneal incisions and to identify factors associated with its occurrence using intraoperative optical coherence tomography (iOCT).
methodsA total of 179 patients (179 eyes) with cataracts underwent coaxial 2.65 mm clear corneal incision phacoemulsification with intraocular lens implantation. iOCT was used for real-time scanning of the corneal main incision, recording DMD occurrence and extent at each procedural step. The full cohort was used for descriptive analyses and to evaluate associations between baseline factors and DMD detected at any intraoperative stage. Irrigation/aspiration (I/A)-related exposures were evaluated in the primary I/A analysis cohort, comprising the 145 eyes that remained DMD-free at I/A initiation. The primary outcome was newly detected DMD, defined as the first detection of DMD during I/A or at any subsequent intraoperative stage. A new parameter, I/A incision-deformation time, was defined as the cumulative duration of instrument-incision engagement accompanied by visible incision deformation during the I/A stage.
resultsIntraoperative DMD was detected in 109 of 179 eyes (60.9%) and was first observed most frequently during I/A (43.1%). In the primary I/A analysis cohort (n = 145), longer I/A incision-deformation time (adjusted odds ratio [aOR] = 1.23; 95% CI, 1.12-1.36; P < 0.001) and greater nuclear hardness (aOR = 4.20; 95% CI, 2.08-8.50; P < 0.001) were independently associated with the occurrence of DMD. I/A incision-deformation time and nuclear hardness showed similar discrimination (area under the curve [AUC], 0.728 and 0.726, respectively), while their exploratory combination yielded an optimism-corrected AUC of 0.800.
conclusionsLonger I/A incision-deformation time and greater nuclear hardness were independently associated with DMD occurrence. I/A incision-deformation time may offer a reproducible quantitative measure of instrument-incision interactions during cataract surgery.
trial registrationChiCTR2100042379.
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