ArticleDiabetes therapy : research, treatment and education of diabetes and related disorders2026
Impact of Ascorbic Acid and Exercise on Accuracy of a Glucose Monitoring System with GDH-FAD Technology in Adult Patients with Type 1 Diabetes Mellitus: A Double-Blinded, Randomized Trial.
Article in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05348928 (A Pilot Study of the Feasibility and Accuracy of the TrueVie Continuous Glucose Monitoring System - A Non-Significant Risk Study), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study of the Feasibility and Accuracy of the TrueVie Continuous Glucose Monitoring System - A Non-Significant Risk Study
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe performance of a new continuous glucose monitoring system (CGM) with flavin adenine dinucleotide-dependent glucose dehydrogenase (GDH-FAD) technology in adults with type 1 diabetes mellitus (T1DM) was assessed, with a focus on the impact of ascorbic acid and exercise on the accuracy of glucose measurements relative to Yellow Springs Instrument (YSI) 2300 control.
methodsAdults with T1DM aged 18-65 years using a stable glucose management treatment regimen for at least 3 months with multiple daily injections or continuous subcutaneous insulin infusion participated in this study at a single center. Participants attended a screening visit and three in-clinic visits for frequent blood sampling with blood glucose measurements using YSI measurements as the reference measurement as endorsed by the Food and Drug Administration (FDA). Participants had two meals at each clinic visit leading to pronounced glucose excursions. On the second and third in-clinic visits, participants performed moderate exercise in between the two meals and were randomized to receive 1000 mg of ascorbic acid orally at either of those visits. Accuracy evaluation included the proportion of CGM values within 15% of YSI glucose values > 100 mg/dL or within 15 mg/dL of YSI values ≤ 100 mg/dL (%15/15), along with %20/20, %30/30, and %40/40 agreement rates (AR) across CGM ranges. The mean absolute difference (MAD) and mean absolute relative difference (MARD) with and without ascorbic acid and exercise, as well as their differences, are presented across glucose ranges.
resultsData from 16 participants were analyzed. In the overall CGM range (35-450 mg/dL), the %20/20 AR was 92.0%. The overall changes in MAD between the exercise/nonexercise and the ascorbic acid/nonascorbic acid conditions were -1.3 mg/dL and -1.1 mg/dL. The overall changes in MARD between those two sets of conditions were -1.5% and -1.6%, respectively, none of which were considered to be clinically relevant. There were no serious adverse events.
conclusionsThis study provides evidence that neither exercise nor ascorbic acid results in any clinically significant interference on glucose measurements using the iCan CGM system.
trial registrationClinicalTrials.gov identifier, NCT05348928.
Indexed as
Identifiers
42853347What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.