Evidence map›Paper›PMID 42853290›Full record

ArticleSurgery today2026

Coronary bypass outcomes in chronic limb-threatening ischemia are significantly worse than in patients with non-critical lower extremity arterial disease.

Kentaro Shirakura, Yuki Setogawa, Ryohei Ushioda, Daisuke Takeyoshi, Masahiro Tsutsui, Shinsuke Kikuchi, Nobuyoshi Azuma, Hiroyuki Kamiya, Shingo Kunioka

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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Kentaro ShirakuraDepartment of Cardiac Surgery, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.
Yuki SetogawaDepartment of Cardiac Surgery, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.
Ryohei UshiodaDepartment of Cardiac Surgery, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan. ryouheihei98@gmail.com.
Daisuke TakeyoshiDepartment of Cardiac Surgery, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.
Masahiro TsutsuiDepartment of Cardiac Surgery, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.
Shinsuke KikuchiDepartment of Vascular Surgery, Asahikawa Medical University, Asahikawa, 078-8510, Japan.
Nobuyoshi AzumaDepartment of Vascular Surgery, Asahikawa Medical University, Asahikawa, 078-8510, Japan.
Hiroyuki KamiyaDepartment of Cardiac Surgery, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.
Shingo KuniokaDepartment of Cardiac Surgery, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLower extremity arterial disease (LEAD) is a risk factor in patients undergoing coronary artery bypass grafting (CABG); however, the impact of chronic limb-threatening ischemia (CLTI), its most advanced stage, remains unclear. We evaluated early and long-term outcomes of CABG in CLTI.

methodWe retrospectively analyzed 334 consecutive patients who underwent isolated CABG between 2014 and 2024. Patients were stratified into three groups: CLTI (n = 22), non-CLTI LEAD (n = 41), and non-LEAD (n = 271). The primary endpoint was long-term survival; the secondary endpoints were 30-day mortality and major adverse cardiac and cerebrovascular events.

resultsThe CLTI group had higher rates of diabetes mellitus (90.9%) and hemodialysis (86.4%) (p < 0.01). Thirty-day mortality was similar (9.1%, 2.4%, and 5.5%; p = 0.52), whereas five-year survival was significantly lower in the CLTI group (39.8% vs. 86.2% and 90.8%; p < 0.01). A Cox analysis showed that age, hemodialysis, and acute myocardial infarction were independent predictors of 5-year survival.

conclusionsCLTI predicts poor long-term survival because of comorbidities. In this high-risk population, individualized strategies balancing the extent of coronary revascularization against operative risk may achieve acceptable early outcomes, although the safety of incomplete/functional revascularization requires confirmation in larger cohorts.

Indexed as

CABGCLTILEAD

Identifiers

PMID42853290

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.