ArticleJournal of bone and mineral metabolism2026
Propionibacterium cheese and bone turnover in active young adults: a randomized-controlled trial.
Article in Journal of bone and mineral metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06688032 (Efficiency Comparison of Jarlsberg- and Norvegia Cheese on Bone Markers, Resting Metabolic Rate, Bone Mineral Density, Muscle Strength and Peak VO2 in Cross-Country Skiers of Both Sexes), which is not on this map. Not yet cited in PubMed.
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Efficiency Comparison of Jarlsberg- and Norvegia Cheese on Bone Markers, Resting Metabolic Rate, Bone Mineral Density, Muscle Strength and Peak VO2 in Cross-Country Skiers of Both Sexes
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Abstract
introductionYoung physically active individuals exposed to prolonged physiological stress and low energy availability are prone to reduced gonadal steroid protection and increased bone turnover. Nutritional strategies that favor positive bone remodeling balance are of clinical interest. Jarlsberg cheese contains Propionibacterium freudenreichii (PF), which produces vitamin K₂ and 1,4-dihydroxy-2-naphthoic acid (DHNA), compounds with potential favorable effects on bone health. MATERIALS AND
methodsIn this 24-week sex-stratified randomized-controlled trial, 60 young physically active adults engaged in endurance training were allocated to daily intake of either Jarlsberg cheese or a nutritionally comparable control cheese without PF. The primary outcome was change in serum total osteocalcin (tOC). Secondary outcomes were changes in carboxylated osteocalcin (cOC), procollagen type 1 N-terminal propeptide (P1NP), cross-linked C-terminal telopeptide of type I collagen (CTX), P1NP/CTX ratio, lumbar spine bone mineral density (BMD), and trabecular bone score (TBS).
resultsAfter 24 weeks, serum tOC was significantly higher in the Jarlsberg group than in controls (38.0 vs. 26.8 ng/mL, p < 0.01). cOC and P1NP/CTX ratio increased in favor of the Jarlsberg group (p = 0.03). Lumbar spine BMD increased in the Jarlsberg group (mean change 0.012 g/cm
conclusionDaily intake of cheese-containing PF was associated with favorable changes in bone turnover markers and increase in lumbar spine BMD. These findings suggest that PF-fermented cheese may support bone metabolism in young individuals exposed to reduced hormonal protection and high bone turnover. PROTOCOL NUMBER: XCS-Jarlsberg/IIA. CLINICALTRIALS: GOV: NCT06688032.
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