In one paragraphArticle in Journal of human immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Signe Bedsted Clemmensen *Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID 0000-0001-9871-149X Lisbeth Aagaard LarsenEpidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID 0000-0002-0426-0569 Marianne NygaardEpidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID 0000-0003-0703-2665 Adrian GervaisLaboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0002-1083-5787 Paul BastardLaboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0002-5926-8437 Anne PuelLaboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0003-2603-0323 Aurelie CobatLaboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0001-7209-6257 Jean-Laurent Casanova *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0002-7782-4169 Kaare Christensen *Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID 0000-0002-5429-5292 Funding
Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6MInborn errors of immunity in patients with life-threatening COVID-19R01AI163029 · NIAID · ROCKEFELLER UNIVERSITY · PI CASANOVA, JEAN-LAURENT, ZHANG, QIAN · 2021 to 2025
$3.7MAarhus UniversityANRS ANRS0629ANRS ANRS-23-PEPR-MIE-0007Battersea and Bowery Advisory GroupBettencourt-Schueller FoundationDanish Agency for Science, Technology and InnovationDanish National Research Foundation DNRF164Fondation du SouffleFrench Foundation for Medical Research EA20170638020French Foundation for Medical Research EQU202503020018French Ministry of Higher Education, Research, and Innovation MESRI-COVID-19French National Research Agency ANR-10-IAHU-01French National Research Agency ANR-10-LABX-62-01French National Research Agency ANR-10-LABX-62-IBEIDFrench National Research Agency ANR-19-CE15-0009-01French National Research Agency ANR-20-CE93-003French National Research Agency ANR-21-RHUS-08French National Research Agency ANR-22-CE15-278 0046French National Research Agency ANR-22-CE92-0004Frimodt-Heineke FoundationGeneral Atlantic FoundationGrandir - Fonds de solidarité pour l'enfanceHORIZON-HLTH-2021-DISEASE-04 program 101057100HORIZON-HLTH-2024-DISEASE-08-20 101191725Howard Hughes Medical InstituteImagine InstituteIndependent Research Fund Denmark 0134-00006BInstitut National de la Santé et de la Recherche MédicaleLundbeck Foundation R268-2016-3927National Program for Research Infrastructure 09-063256NCATS NIH HHS UL1 TR001866NIAID NIH HHS R01 AI163029NIH HHS R01AI163029NIH HHS UL1TR001866Novo Nordisk Foundation NNF20OC0064890Novo Nordisk Foundation NNF21OC0067157Novo Nordisk Foundation NNF25OC0107335Paris Cité UniversityREACTing-INSERMSCOR Corporate Foundation for ScienceSquare FoundationStavros Niarchos FoundationSt. Giles FoundationThe Rockefeller University
6 · The paper itselfAbstract
Autoantibodies (auto-Abs) neutralizing type I interferons (IFN-I) underlie various life-threatening viral infections, and the prevalence of these auto-Abs rises sharply between 65 and 70 years of age. We investigated the familial aggregation of neutralizing IFN-I auto-Abs by assessing concordance rates in Danish older twins, including 3,270 twins aged 65-96 years in a sample comprising 1,318 intact twin pairs (2,636 individuals) and 634 twins from broken twin pairs (634 individuals). Neutralizing IFN-I auto-Abs were detected in 1.5% (50/3,270) of all twins tested, including 1.4% (37/2,636) in twins from intact pairs and 2.1% (13/634) in twins from broken pairs. A total of 50 twins had neutralizing IFN-I auto-Abs, including one concordant monozygotic pair and 35 discordant pairs, yielding a low overall concordance rate. A slight, but nonsignificant, increase in mortality was associated with harboring neutralizing IFN-I auto-Abs. Collectively, these findings do not reveal any familial aggregation of IFN-I auto-Abs, arguing against a strong germline genetic etiology of IFN-I auto-Abs in older adults.
Identifiers
PMID42853147
PMCPMC13651747
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